Ptk7 - PTK7 protein tyrosine kinase 7 Gene

Also Known as chz; mPTK7/CCK4; 8430404F20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71461

Summary

Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within several processes, including animal organ development; axis elongation; and morphogenesis of an epithelium. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; nervous system; paraxial mesenchyme; reproductive system; and sensory organ. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]

Ptk7 Products (1)

mRNA Protein Name
NM_175168.4 NP_780377.1 inactive tyrosine-protein kinase 7 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables kinase activity IDA
IDA: Inferred from direct assay
15019986 MGI
NOT enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
15019986 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axis elongation IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within convergent extension IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within establishment of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
15229603 MGI
acts upstream of or within establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
27002738 MGI
acts upstream of or within lung-associated mesenchyme development IMP
IMP: Inferred from mutant phenotype
20704721 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
15229603 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
15229603 MGI
NOT acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15019986 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within wound healing IGI
IGI: Inferred from genetic interaction
20643356 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
20215345 MGI
located in membrane IDA
IDA: Inferred from direct assay
20704721 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
20215345 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive tyrosine-protein kinase 7

  • protein chuzhoi

  • protein-tyrosine kinase 7

  • pseudo tyrosine kinase receptor 7

  • receptor tyrosine kinase-like protein

  • tyrosine-protein kinase-like 7

Recombinant Ptk7 Proteins

Cat. No. Product Name Accession Purity
HY-P78761 PTK7 Protein, Mouse (HEK293, His) Q8BKG3 (A23-T696) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99829 Cofetuzumab pelidotin Inhibitor 99.18% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160493 PTK7/β-catenin-IN-6 Inhibitor / Unkown
HY-160488 PTK7/β-catenin-IN-1 Inhibitor 99.99% Unkown
HY-160489 PTK7/β-catenin-IN-2 Inhibitor 96.96% Unkown
HY-182914 NGI-189 99.29% Unkown
HY-RS11404 PTK7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17543 Ptk7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24001 Ptk7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99828 Cofetuzumab 99.31% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptk7 NCBI NCBI:5754