Cul4b - cullin 4B Gene

Also Known as CUL-4B; mKIAA0695; 2700050M05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72584

Summary

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Predicted to contribute to damaged DNA binding activity. Involved in ribosome biogenesis. Acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle and positive regulation of protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cul4B-RING E3 ubiquitin Ligase complex. Is expressed in brain and liver. Used to study intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B). [provided by Alliance of Genome Resources, Apr 2022]

Cul4b Products (2)

mRNA Protein Name
NM_001110142.1 NP_001103612.1 cullin-4B
NM_028288.5 NP_082564.3 cullin-4B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30442713 MGI
Biological Process GO Annotation Evidence References Source
involved in astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
26025376 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
26025376 MGI
acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19056892 MGI
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
18602923 MGI
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
35197566 MGI
involved in ribosome biogenesis IMP
IMP: Inferred from mutant phenotype
26711351 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
35197566 MGI
Cellular Component GO Annotation Evidence References Source
part of Cul4A-RING E3 ubiquitin ligase complex EXP
EXP: Inferred from Experiment
22118460 MGI
part of Cul4B-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
35197566 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cullin-4B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150184 And1-IN-1 Inhibitor 98.01% Unkown
HY-RS03363 CUL4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22461 Cul4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28984 Cul4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cul4b NCBI NCBI:8450