DDB1 ligand-3
DDB1 ligand-3 is a molecular glue compound. DDB1 ligand-3 binds the CDK12/13:CCNK complex and induces its interaction with the DDB1:CUL4B E3 ubiquitin ligase, thereby promoting CCNK ubiquitination and proteasomal degradation, and exhibits nanomolar-level antiproliferative activity in breast cancer cell lines.
For research use only. We do not sell to patients.
- CAS No.: 3076933-25-7
- Formula: C19H20ClN5O2
- Molecular Weight:385.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
In Vitro
yl) propanamide Enantiomer 2) induces CCNK degradation in HEK293T cells with Nluc-tagged CCNK: DC50 < 1 nM; and exhibits potent cytotoxic activity in two breast cancer cell lines: Hs-578T EC50 of 1-10 nM and BT-474 EC50 of 1-10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3076933-25-7
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Molecular Weight 385.85
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Formula C19H20ClN5O2
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SMILES
C[C@H](C1=CN(C2=CC(OC)=CC(Cl)=C2)N=C1)C(NC3=NNC(C4CC4)=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DDB1 ligand-3 Related Classifications
HY-190236 Related Classifications
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