UCK2 - uridine-cytidine kinase 2 Gene

Also Known as UK; UMPK; TSA903

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7371

About UCK2

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:165,827,614-165,911,618 (from NCBI)

This gene has 9 transcripts (splice variants), 261 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 6.8), small intestine (RPKM 6.1) and 25 other tissues.

Summary

This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]

UCK2 Products (2)

mRNA Protein Name
NM_001363568.2 NP_001350497.1 uridine-cytidine kinase 2 isoform 2
NM_012474.5 NP_036606.2 uridine-cytidine kinase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytidine kinase activity IDA
IDA: Inferred from direct assay
11306702 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15130468 GOA
enables uridine kinase activity IDA
IDA: Inferred from direct assay
11306702 GOA
Biological Process GO Annotation Evidence References Source
involved in CTP salvage IDA
IDA: Inferred from direct assay
11306702 GOA
involved in UMP salvage IDA
IDA: Inferred from direct assay
11306702 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCK2 Protein Structure

PRK

PRK: Phosphoribulokinase / Uridine kinase family (22 - 216)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

uridine-cytidine kinase 2

  • cytidine monophosphokinase 2

UCK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UCK2 Q9BZX2 UCK2 Homo sapiens Q9BZX2
Y2H Prey Pooling
32296183
Intra
UCK2 Q9BZX2 VARS2 Homo sapiens Q5ST30
Anti Tag CoIP
33961781
Intra
UCK2 Q9BZX2 VARS2 Homo sapiens Q5ST30
Anti Tag CoIP
28514442
Intra
UCK2 Q9BZX2 IAH1 Homo sapiens Q2TAA2
Anti Tag CoIP
33961781
Intra
UCK2 Q9BZX2 IAH1 Homo sapiens Q2TAA2
Anti Tag CoIP
28514442
Intra
UCK2 Q9BZX2 TSC22D1 Homo sapiens Q15714
Anti Bait CoIP
17353931
Intra
UCK2 Q9BZX2 UCK2 Homo sapiens Q9BZX2
Validated Y2H
32296183
Intra
UCK2 Q9BZX2 UCK1 Homo sapiens Q9HA47
Anti Tag CoIP
33961781
Intra
UCK2 Q9BZX2 UCKL1 Homo sapiens Q9NWZ5
Anti Tag CoIP
33961781
Intra
UCK2 Q9BZX2 UCK2 Homo sapiens Q9BZX2
Y2H Array
32296183
Intra
UCK2 Q9BZX2 UCK1 Homo sapiens Q9HA47
Anti Tag CoIP
28514442
Intra
UCK2 Q9BZX2 UCKL1 Homo sapiens Q9NWZ5
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148394 UCK2 Inhibitor-1 Inhibitor 96.32% Unkown
HY-148396 UCK2 Inhibitor-3 98.65% Unkown
HY-78574 N-Benzoylcytidine 99.50% Unkown
HY-148395 UCK2 Inhibitor-2 Inhibitor 99.25% Unkown
HY-RS15404 UCK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18374 Uck2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24854 Uck2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UCK2 VGNC VGNC:78718
Felis catus UCK2 VGNC VGNC:66797
Canis familiaris UCK2 VGNC VGNC:56145
Mus musculus UCK2 MGD MGI:1931744
Rattus norvegicus UCK2 RGD RGD:620742
Bos taurus UCK2 VGNC VGNC:36635
Others UCK2 NCBI