1. Metabolic Enzyme/Protease
  2. Dihydroorotate Dehydrogenase
  3. UCK2 Inhibitor-2

UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells.

For research use only. We do not sell to patients.

UCK2 Inhibitor-2 Chemical Structure

UCK2 Inhibitor-2 Chemical Structure

CAS No. : 866842-71-9

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Description

UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells[1].

IC50 & Target

IC50: 3.8 µM (UCK2)[1]

In Vitro

UCK2 Inhibitor-2 (compound 20874830) shows 52% inhibition of uridine salvage in K562 cells at a concentration of 50 µM. The inhibition of DHODH increases uridine salvage, while, UCK2 inhibitor UCK2 Inhibitor-2 (compound 20874830) can suppress this increase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

497.56

Formula

C28H23N3O4S

CAS No.
SMILES

O=C(C1=CC(NC(CSC2=C3CC4=C(C(C)=CC=C4)OC3=NC(C5=CC=C(C)C=C5)=N2)=O)=CC=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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UCK2 Inhibitor-2 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
UCK2 Inhibitor-2
Cat. No.:
HY-148395
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