USF1 - upstream transcription factor 1 Gene

Also Known as UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7391

About USF1

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,039,251-161,045,977 (from NCBI)

This gene has 11 transcripts (splice variants), 220 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 29.9), lymph node (RPKM 25.8) and 25 other tissues.

Summary

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

USF1 Products (3)

mRNA	Protein	Name
NM_001276373.2	NP_001263302.1	upstream stimulatory factor 1 isoform 1
NM_007122.5	NP_009053.1	upstream stimulatory factor 1 isoform 1
NM_207005.3	NP_996888.1	upstream stimulatory factor 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	7852331	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	2249772	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	8576131	GOA
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	8576131	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19303849	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	19303849	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19303849	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	8576131	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	8576131	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19303849	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	27141965	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	2249772	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	7852331	GOA
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	19303849	GOA
involved in glucose mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	7852331	GOA
involved in late viral transcription	IDA IDA: Inferred from direct assay	2249772	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	7852331	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	2249772	GOA
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	12917334	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	27141965	GOA
located in nucleus	IDA IDA: Inferred from direct assay	2249772	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	19303849	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USF1 Protein Structure

HLH

0
100
200
310 a.a.

Protein Preferred Names	Protein Names
upstream stimulatory factor 1	class B basic helix-loop-helix protein 11

USF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	USF1	P22415	FOS	Homo sapiens	Q6FG41	Validated Y2H	25416956
Intra	USF1	P22415	FOS	Homo sapiens	Q6FG41	Y2H Array	25416956
Intra	USF1	P22415	FOS	Homo sapiens	Q6FG41	Y2H Prey Pooling	25416956
Intra	USF1	P22415	MAP3K7CL	Homo sapiens	P57077-4	Validated Y2H	32296183
Intra	USF1	P22415	MAP3K7CL	Homo sapiens	P57077-4	Y2H Array	32296183
Intra	USF1	P22415	MAP3K7CL	Homo sapiens	P57077-4	Y2H Prey Pooling	32296183
Intra	USF1	P22415	USF1	Homo sapiens	P22415	Y2H Prey Pooling	32296183
Intra	USF1	P22415	PRKDC	Homo sapiens	P78527	Anti Tag CoIP	19303849
Intra	USF1	P22415	USF1	Homo sapiens	P22415	Y2H Array	32296183
Intra	USF1	P22415	KAT2B	Homo sapiens	Q92831	Anti Bait CoIP	19303849
Intra	USF1	P22415	FOSL1	Homo sapiens	P15407	Y2H Array	32296183
Intra	USF1	P22415	USF1	Homo sapiens	P22415	Y2H Array	25416956
Intra	USF1	P22415	USF2	Homo sapiens	Q15853	Anti Bait CoIP	19303849
Intra	USF1	P22415	KAT2B	Homo sapiens	Q92831	Anti Tag CoIP	19303849
Intra	USF1	P22415	PRKDC	Homo sapiens	P78527	Anti Bait CoIP	19303849
Intra	USF1	P22415	FOSL1	Homo sapiens	P15407	Y2H Prey Pooling	32296183
Intra	USF1	P22415	USF2	Homo sapiens	Q15853	Anti Tag CoIP	19303849
Intra	USF1	P22415	USF2	Homo sapiens	Q15853	Anti Tag CoIP	33961781
Intra	USF1	P22415	KAT2B	Homo sapiens	Q92831	Acetylase Assay	19303849
Intra	USF1	P22415	USF1	Homo sapiens	P22415	Validated Y2H	32296183
Intra	USF1	P22415	LAP3	Homo sapiens	P28838	Y2H Prey Pooling	32296183
Intra	USF1	P22415	LAP3	Homo sapiens	P28838	Validated Y2H	32296183
Intra	USF1	P22415	LAP3	Homo sapiens	P28838	Y2H Array	32296183
Intra	USF1	P22415	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	USF1	P22415	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	USF1	P22415	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	USF1	P22415	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	USF1	P22415	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	USF1	P22415	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	USF1	P22415	SNW1	Homo sapiens	Q13573	Y2H Array	32296183
Intra	USF1	P22415	SNW1	Homo sapiens	Q13573	Y2H Prey Pooling	32296183
Intra	USF1	P22415	SNW1	Homo sapiens	Q13573	Validated Y2H	32296183
Intra	USF1	P22415	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	USF1	P22415	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	USF1	P22415	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant USF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700514	USF1 Protein, Human (His)	P22415 (G3-N310)	≥ 90%, as determined by reducing SDS-PAGE.

USF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83564	USF1 Antibody (YA3309)	WB	Human, Mouse
HY-P83564A	USF1 Antibody (YA3309)(PBS only)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Hyperlipidemia, Familial Combined, 1	Hyperlipidemia, Familial Combined, Susceptibility To Hyperlipidemia, Combined, 1 Hyperlipidemia, Familial Combined FCHL1 Hyplip1 Familial Combined Hyperlipidemia Type 1 Hyperlipidemia Combined, 1 Hyperlipoproteinemia Type Iib
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15513	USF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19651	Usf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26144	Usf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	USF1	VGNC	VGNC:53132
Bos taurus	USF1	VGNC	VGNC:55695
Macaca mulatta	USF1	VGNC	VGNC:100184
Rattus norvegicus	USF1	RGD	RGD:620974
Mus musculus	USF1	MGD	MGI:99542
Felis catus	USF1	VGNC	VGNC:107960
Others	USF1	NCBI