Kdm4c - lysine (K)-specific demethylase 4C Gene

Also Known as Gasc1; Jmjd2c; 2410141F18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76804

Summary

Enables Androgen Receptor binding activity; enzyme binding activity; and Histone Demethylase activity. Acts upstream of or within several processes, including blastocyst formation; histone H3-K9 demethylation; and negative regulation of histone H3-K9 trimethylation. Located in pericentric heterochromatin. Is expressed in early conceptus; eye; genitourinary system; hippocampus; and rib. Human ortholog(s) of this gene implicated in autistic disorder; breast cancer; carcinoma (multiple); head and neck cancer; and withdrawal disorder. Orthologous to human KDM4C (lysine demethylase 4C). [provided by Alliance of Genome Resources, Apr 2022]

Kdm4c Products (3)

mRNA Protein Name
NM_001172095.1 NP_001165566.1 lysine-specific demethylase 4C isoform 2
NM_001356561.1 NP_001343490.1 lysine-specific demethylase 4C isoform 3
NM_144787.2 NP_659036.1 lysine-specific demethylase 4C isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
17277772 MGI
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
16738407 MGI
enables histone H3K9 demethylase activity IMP
IMP: Inferred from mutant phenotype
17938240 MGI
enables histone demethylase activity IDA
IDA: Inferred from direct assay
19144645 MGI
enables nuclear androgen receptor binding IPI
IPI: Inferred from physical interaction
17277772 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blastocyst formation IMP
IMP: Inferred from mutant phenotype
19696013 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17938240 MGI
acts upstream of or within regulation of stem cell differentiation IDA
IDA: Inferred from direct assay
17938240 MGI
acts upstream of or within stem cell population maintenance IGI
IGI: Inferred from genetic interaction
17938240 MGI
Cellular Component GO Annotation Evidence References Source
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
16738407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 4C

  • [histone H3]-trimethyl-L-lysine(9) demethylase 4C

  • gene amplified in squamous cell carcinoma 1

  • jmjC domain-containing histone demethylation protein 3C

  • jumonji domain containing 2C

  • jumonji domain-containing protein 2C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12304 IOX1 Inhibitor 99.89% Unkown
HY-104048 QC6352 Inhibitor 99.13% Unkown
HY-116761 GSK467 Inhibitor 99.34% Unkown
HY-148807 Zavondemstat 99.29% Unkown
HY-107573 KDM2/7-IN-1 Inhibitor 99.9% Unkown
HY-146148 KDM4C-IN-1 Inhibitor 98.13% Unkown
HY-120766 NCDM-32B Inhibitor 97.0% Unkown
HY-148807A Zavondemstat L-lysine / Unkown
HY-RS07215 KDM4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173135 PROTAC KDM4 degrader-1 / Unkown
HY-116796 KDM4C-IN-2 Inhibitor 97.31% Unkown
HY-148807C Zavondemstat sodium / Unkown
HY-183928 EPZ020809 Inhibitor / Unkown
HY-RS17833 Kdm4c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24301 Kdm4c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm4c NCBI NCBI:23081