3 Results for "

7694

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "7694" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-N7694
CAS No.: 97871-44-8
Isotoosendanin is an orally active TGFβR1 inhibitor and abrogating its kinase activity (IC50 = 6732 nM). Isotoosendanin inhibits the JAK/STAT3 signaling pathway by directly targeting SHP-2, enhancing its stability, and reducing its ubiquitination. Isotoosendanin inhibits TGF-β-induced reduces the migration, invasion, and metastasis in triple-negative breast cancer (TNBC) cells. Isotoosendanin exhibits anti-tumor efficacy in TNBC xenograft models and A549 xenograft tumors. Isotoosendanin exhibits significant anti-inflammatory effects in acetic acid-induced vascular permeability and λ-carrageenan-induced hind paw edema tests. Isotoosendanin can be used for the study of non-small cell lung cancer (NSCLC), TNBC and inflammation .
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Cat. No.: HY-P7694
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuPRADC1, His; Protease-associated domain-containing protein 1; PRADC1; C2orf7
Species:  
Source:  
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Cat. No.: HY-P88009
Synonyms: Protein farnesyltransferase subunit beta, FTase-beta, CAAX farnesyltransferase subunit beta, Ras proteins prenyltransferase subunit beta, FNTB

Host:  

Rabbit

Application:  

WB, FC, ICC/IF

Reactivity:  

Human

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