DDX39B - DExD-box helicase 39B Gene

Also Known as BAT1; UAP56; D6S81E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7919

About DDX39B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,530,226-31,542,003 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele, 153 orthologues and 38 paralogues. Ubiquitous expression in endometrium (RPKM 76.9), ovary (RPKM 76.7) and 25 other tissues.

Summary

This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]

DDX39B Products (2)

mRNA	Protein	Name
NM_004640.7	NP_004631.1	spliceosome RNA helicase DDX39B
NM_080598.6	NP_542165.1	spliceosome RNA helicase DDX39B

DDX39B Protein Structure

DEAD

Helicase_C

0
100
200
300
400
428 a.a.

Protein Preferred Names	Protein Names
spliceosome RNA helicase DDX39B	56 kDa U2AF65-associated protein

DDX39B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DDX39B	Q13838	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	DDX39B	Q13838	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	DDX39B	Q13838	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	DDX39B	Q13838	LUZP4	Homo sapiens	Q9P127	Y2H Array	32296183
Intra	DDX39B	Q13838	LUZP4	Homo sapiens	Q9P127	Y2H Prey Pooling	32296183
Intra	DDX39B	Q13838	LUZP4	Homo sapiens	Q9P127	Validated Y2H	32296183
Intra	DDX39B	Q13838	API5	Homo sapiens	Q9BZZ5	Anti Tag CoIP	35271311
Intra	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Prey Pooling	32296183
Intra	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2-3	Validated Y2H	32296183
Intra	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Array	32296183
Intra	DDX39B	Q13838	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	DDX39B	Q13838	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	DDX39B	Q13838	SARNP	Homo sapiens	P82979	Y2H	14667819
Intra	DDX39B	Q13838	SARNP	Homo sapiens	P82979	Anti Tag CoIP	35271311
Intra	DDX39B	Q13838	ALYREF	Homo sapiens	Q86V81	Anti Tag CoIP	35271311
Intra	DDX39B	Q13838	ALYREF	Homo sapiens	Q86V81	Y2H	14667819
Intra	DDX39B	Q13838	ALYREF	Homo sapiens	Q86V81	Pull Down	11979277
Intra	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2	Y2H	14667819
Intra	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2	Crosslink	30021884
Intra	DDX39B	Q13838	CHTOP	Homo sapiens	Q9Y3Y2	Pull Down	23299939
Intra	DDX39B	Q13838	DDX39A	Homo sapiens	O00148	Y2H	14667819
Intra	DDX39B	Q13838	THOC1	Homo sapiens	Q96FV9	Anti Tag CoIP	35271311
Intra	DDX39B	Q13838	THOC1	Homo sapiens	Q96FV9	Pull Down	11979277
Intra	DDX39B	Q13838	SNRPA	Homo sapiens	P09012	Y2H Array	32296183
Intra	DDX39B	Q13838	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	32296183
Intra	DDX39B	Q13838	FYTTD1	Homo sapiens	Q96QD9	Anti Bait CoIP	21814512
Intra	DDX39B	Q13838	FYTTD1	Homo sapiens	Q96QD9	Anti Tag CoIP	35271311
Intra	DDX39B	Q13838	FYTTD1	Homo sapiens	Q96QD9	Pull Down	21814512

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DDX39B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71534	DDX39B Protein, Human (GST)	Q13838 (A2-V251)	≥ 90%, as determined by reducing SDS-PAGE.

DDX39B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82725	DDX39B Antibody (YA2470)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Anterior Horn Cell Disease
Lethal Congenital Contracture Syndrome 1	LCCS1 Multiple Contracture Syndrome, Finnish Type Lccs Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures Lethal Congenital Contracture Syndrome Type 1 Herva Disease Multiple Contracture Syndrome Finnish Type Contracture Syndrome, Lethal, Congenital, Type 1
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03645	DDX39B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20544	Ddx39b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27052	Ddx39b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DDX39B	VGNC	VGNC:71621
Bos taurus	DDX39B	VGNC	VGNC:27965
Felis catus	DDX39B	VGNC	VGNC:61407
Rattus norvegicus	DDX39B	RGD	RGD:70923
Canis familiaris	DDX39B	VGNC	VGNC:39855
Mus musculus	DDX39B	MGD	MGI:99240
Others	DDX39B	NCBI