API5 - apoptosis inhibitor 5 Gene

Also Known as AAC11; AAC-11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8539

About API5

Cytogenetic location: 11p12 Genomic coordinates (GRCh38): 11:43,311,996-43,344,529 (from NCBI)

This gene has 11 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in thyroid (RPKM 18.0), lymph node (RPKM 15.7) and 25 other tissues.

Summary

This gene encodes an Apoptosis inhibitory protein whose expression prevents Apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced Apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

API5 Products (4)

mRNA Protein Name
NM_001142930.2 NP_001136402.1 apoptosis inhibitor 5 isoform a
NM_001142931.2 NP_001136403.1 apoptosis inhibitor 5 isoform c
NM_001243747.2 NP_001230676.1 apoptosis inhibitor 5 isoform d
NM_006595.4 NP_006586.1 apoptosis inhibitor 5 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fibroblast growth factor binding IPI
IPI: Inferred from physical interaction
11075807 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19387494 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11075807 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11075807 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

API5 Protein Structure

API5

API5: Apoptosis inhibitory protein 5 (API5) (4 - 516)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 524 a.a.
Protein Preferred Names Protein Names

apoptosis inhibitor 5

  • FIF

API5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
API5 Q9BZZ5 DDX39B Homo sapiens Q13838
Crosslink
30021884
Intra
API5 Q9BZZ5 ACIN1 Homo sapiens Q9UKV3-3
Anti Tag CoIP
19387494
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Asbestos-Related Lung Carcinoma
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00819 API5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta API5 VGNC VGNC:99544
Bos taurus API5 VGNC VGNC:26015
Canis familiaris API5 VGNC VGNC:37985
Felis catus API5 VGNC VGNC:67744
Rattus norvegicus API5 RGD RGD:1309772
Mus musculus API5 MGD MGI:1888993
Others API5 NCBI