LRRC2 - leucine rich repeat containing 2 Gene
Species: Homo sapiens
About LRRC2
This gene has 5 transcripts (splice variants), 192 orthologues and 31 paralogues. Biased expression in heart (RPKM 15.6), thyroid (RPKM 11.1) and 9 other tissues.
Summary
This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the Ras suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]
LRRC2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_024512.5 | NP_078788.2 | leucine-rich repeat-containing protein 2 |
LRRC2 Protein Structure
LRR_4: Leucine Rich repeats (2 copies) (147 - 184)
LRR_1: Leucine Rich Repeat (191 - 213)
LRR_8: Leucine rich repeat (216 - 272)
- 0
- 100
- 200
- 300
- 371 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
leucine-rich repeat-containing protein 2 |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | LRRC2 | VGNC | VGNC:110357 |
| Rattus norvegicus | LRRC2 | RGD | RGD:1311716 |
| Canis familiaris | LRRC2 | VGNC | VGNC:81275 |
| Mus musculus | LRRC2 | MGD | MGI:1921499 |
| Felis catus | LRRC2 | VGNC | VGNC:80613 |
| Bos taurus | LRRC2 | VGNC | VGNC:59173 |
| Others | LRRC2 | NCBI |