OBI1 - ORC ubiquitin ligase 1 Gene

Also Known as RNF219; C13orf7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79596

About OBI1

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:78,614,289-78,659,155 (from NCBI)

This gene has 1 transcript (splice variant) and 199 orthologues. Ubiquitous expression in testis (RPKM 8.1), brain (RPKM 4.8) and 25 other tissues.

Summary

Enables chromatin binding activity and ubiquitin-protein transferase activity. Involved in protein autoubiquitination; protein monoubiquitination; and regulation of DNA replication. Located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

OBI1 Products (1)

mRNA Protein Name
NM_024546.4 NP_078822.3 ORC ubiquitin ligase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
31160578 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
31160578 GOA
Biological Process GO Annotation Evidence References Source
involved in protein autoubiquitination IDA
IDA: Inferred from direct assay
31160578 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
31160578 GOA
involved in regulation of DNA replication IDA
IDA: Inferred from direct assay
31160578 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
31160578 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OBI1 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (17 - 56)

  • 0
  • 200
  • 400
  • 600
  • 726 a.a.
Protein Preferred Names Protein Names

ORC ubiquitin ligase 1

  • ring finger protein 219

OBI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OBI1 Q5W0B1 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
OBI1 Q5W0B1 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
OBI1 Q5W0B1 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
OBI1 Q5W0B1 TCEANC Homo sapiens Q8N8B7
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09734 OBI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus OBI1 MGD MGI:1919736
Rattus norvegicus OBI1 RGD RGD:1564706
Bos taurus OBI1 VGNC VGNC:34054
Macaca mulatta OBI1 VGNC VGNC:76782
Canis familiaris OBI1 VGNC VGNC:45660
Felis catus OBI1 VGNC VGNC:102276
Others OBI1 NCBI