2. Gene
  3. ACSS3 - acyl-CoA synthetase short chain family member 3 Gene

ACSS3 - acyl-CoA synthetase short chain family member 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 79611 | Gene type: protein coding

About ACSS3

Cytogenetic location: 12q21.31 Genomic coordinates (GRCh38): 12:81,077,871-81,261,210 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 13 paralogues. Broad expression in fat (RPKM 16.6), liver (RPKM 14.1) and 17 other tissues.

Summary

Enables propionate-CoA ligase activity. Predicted to be involved in ketone body biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ACSS3 Products(3)

mRNA Protein Name
NM_001330242.2 NP_001317171.1 acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 2 precursor
NM_001330243.2 NP_001317172.1 acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 3
NM_024560.4 NP_078836.1 acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1 precursor

ACSS3 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (124 - 561)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (571 - 649)

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  • 686 a.a.
Protein Preferred Names Protein Names

acyl-CoA synthetase short-chain family member 3, mitochondrial

AMP-binding enzyme, 33217

Related Diseases

Diseases Alias
Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome

Mva Syndrome

Mosaic Variegated Aneuplody Microcephaly Syndrome

Warburton Anyane Yeboa Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145953 VY-3-135 Inhibitor 98.51% Unkown
HY-RS00212 ACSS3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ACSS3 VGNC VGNC:25572
Mus musculus ACSS3 MGD MGI:2685720
Felis catus ACSS3 VGNC VGNC:59540
Macaca mulatta ACSS3 VGNC VGNC:69532
Rattus norvegicus ACSS3 RGD RGD:1307051