ACSS3 - acyl-CoA synthetase short chain family member 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79611

About ACSS3

Cytogenetic location: 12q21.31 Genomic coordinates (GRCh38): 12:81,077,871-81,261,210 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 13 paralogues. Broad expression in fat (RPKM 16.6), liver (RPKM 14.1) and 17 other tissues.

Summary

Enables propionate-CoA Ligase activity. Predicted to be involved in ketone body biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

ACSS3 Products (3)

mRNA Protein Name
NM_001330242.2 NP_001317171.1 acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 2 precursor
NM_001330243.2 NP_001317172.1 acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 3
NM_024560.4 NP_078836.1 acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables propionate-CoA ligase activity IDA
IDA: Inferred from direct assay
28003429 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
28003429 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACSS3 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (124 - 561)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (571 - 649)

  • 0
  • 200
  • 400
  • 600
  • 686 a.a.
Protein Preferred Names Protein Names

acyl-CoA synthetase short-chain family member 3, mitochondrial

  • AMP-binding enzyme, 33217

Related Diseases

Diseases Alias
Mosaic Variegated Aneuploidy Syndrome

  • Warburton-Anyane-Yeboa Syndrome

  • Mva Syndrome

  • Mosaic Variegated Aneuplody Microcephaly Syndrome

  • Warburton Anyane Yeboa Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145953 VY-3-135 Inhibitor 99.62% Unkown
HY-RS00212 ACSS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19979 Acss3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26483 Acss3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ACSS3 VGNC VGNC:25572
Mus musculus ACSS3 MGD MGI:2685720
Felis catus ACSS3 VGNC VGNC:59540
Macaca mulatta ACSS3 VGNC VGNC:69532
Rattus norvegicus ACSS3 RGD RGD:1307051
Others ACSS3 NCBI