DHX40 - DEAH-box helicase 40 Gene

Also Known as PAD; DDX40; ARG147

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79665

About DHX40

Cytogenetic location: 17q23.1 Genomic coordinates (GRCh38): 17:59,565,610-59,608,345 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 20.7), thyroid (RPKM 19.9) and 25 other tissues.

Summary

This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Oct 2009]

DHX40 Products (2)

mRNA Protein Name
NM_001166301.2 NP_001159773.1 probable ATP-dependent RNA helicase DHX40 isoform 2
NM_024612.5 NP_078888.4 probable ATP-dependent RNA helicase DHX40 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX40 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (55 - 216)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (312 - 400)

HA2

HA2: Helicase associated domain (HA2) (462 - 547)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (592 - 698)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DHX40

  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 40 (RNA helicase)

DHX40 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DHX40 Q8IX18 PSTPIP1 Homo sapiens O43586
Y2H Array
32296183
Intra
DHX40 Q8IX18 PSTPIP1 Homo sapiens O43586
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 17

  • RP17

  • Retinitis Pigmentosa-17

  • Retinitis Pigmentosa, Type 17
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175599 Z6466608628 / Unkown
HY-175599A Z6466608628 hydrochloride 99.25% Unkown
HY-RS03758 DHX40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DHX40 VGNC VGNC:61484
Rattus norvegicus DHX40 RGD RGD:1359618
Canis familiaris DHX40 VGNC VGNC:39949
Macaca mulatta DHX40 VGNC VGNC:104597
Mus musculus DHX40 MGD MGI:1914737
Bos taurus DHX40 VGNC VGNC:28056
Others DHX40 NCBI