MPIG6B - megakaryocyte and platelet inhibitory receptor G6b Gene

Also Known as G6b; NG31; G6b-B; THAMY; C6orf25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80739

About MPIG6B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,720,296-31,726,714 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 89 orthologues and is associated with 1 phenotype. Broad expression in skin (RPKM 2.2), bone marrow (RPKM 1.5) and 14 other tissues.

Summary

This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MPIG6B Products (6)

mRNA Protein Name
NM_025260.4 NP_079536.2 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-A precursor
NM_138272.3 NP_612116.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-B precursor
NM_138273.3 NP_612117.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-C precursor
NM_138274.3 NP_612118.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-D precursor
NM_138275.3 NP_612119.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-E precursor
NM_138277.3 NP_612121.1 megakaryocyte and platelet inhibitory receptor G6b isoform G6b-G precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23112346 GOA
Biological Process GO Annotation Evidence References Source
involved in erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
27743390 GOA
involved in megakaryocyte differentiation IMP
IMP: Inferred from mutant phenotype
27743390 GOA
involved in negative regulation of signal transduction IDA
IDA: Inferred from direct assay
18955485 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11544253 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPIG6B Protein Structure

G6B

G6B: G6B family (18 - 241)

  • 0
  • 100
  • 200
  • 241 a.a.
Protein Preferred Names Protein Names

megakaryocyte and platelet inhibitory receptor G6b

  • immunoglobulin receptor

Recombinant MPIG6B Proteins

Cat. No. Product Name Accession Purity
HY-P75784 G6B Protein, Human (HEK293, Fc) O95866-1/NP_612116.1 (N18-Q142) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75785 G6B Protein, Human (HEK293, His) O95866-1/NP_612116.1 (N18-Q142) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Thrombocytopenia, Anemia, And Myelofibrosis

  • THAMY
Myelofibrosis

  • Primary Myelofibrosis

  • Agnogenic Myeloid Metaplasia

  • Idiopathic Myelofibrosis

  • Myeloid Metaplasia

  • Myelofibrosis With Myeloid Metaplasia

  • Osteomyelofibrosis

  • Megakaryocytic Myelosclerosis

  • Myelosclerosis

  • Chronic Idiopathic Myelofibrosis

  • Myelofibrosis, Idiopathic

  • Myelofibrosis With Myeloid Metaplasia, Somatic

  • Myelofibrosis, Somatic

  • Aleukemic Myelosis

  • Bone Marrow Fibrosis

  • MYELOF

  • MMM

  • Agnogenic Myeloid Metaplasia With Myelofibrosis

  • Ammm

  • Myelosclerosis With Myeloid Metaplasia

  • Myelofibrosis Nos
Gray Platelet Syndrome

  • Platelet Alpha-Granule Deficiency

  • GPS

  • Bdplt4

  • Bleeding Disorder, Platelet-Type, 4

  • Grey Platelet Syndrome

  • Platelet-Type Bleeding Disorder 4

  • Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins

  • Deficient Alpha Granule Syndrome

  • Platelet Alpha Granule Deficiency

  • Platelet Granule Defect

  • Alpha Storage Pool Deficiency

  • Bleeding Disorder Platelet-Type 4
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Pseudo-Von Willebrand Disease

  • Bdplt3

  • Von Willebrand Disease, Platelet-Type

  • VWDP

  • Platelet-Type Bleeding Disorder 3

  • Platelet Type-Von Willebrand Disease

  • Pt-Vwd

  • Von Willebrand Disease Platelet-Type

  • Von Willebrand Disease, Platelet Type

  • Pseudo Von Willebrand Disease

  • Bleeding Disorder, Platelet-Type, 3

  • Pseudo-Von Willebrand Disease Type 2b

  • Bleeding Disorder Platelet-Type 3

  • Pseudo-Vwd
Pancytopenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08615 MPIG6B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20180 Mpig6b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26684 Mpig6b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MPIG6B RGD RGD:1303269
Bos taurus MPIG6B VGNC VGNC:31577
Felis catus MPIG6B VGNC VGNC:63572
Mus musculus MPIG6B MGD MGI:2146995
Macaca mulatta MPIG6B VGNC VGNC:74736
Canis familiaris MPIG6B VGNC VGNC:49683
Others MPIG6B NCBI