PDE1A - phosphodiesterase 1A Gene

Also Known as 3-RACEclone8phosphodiesterase1A; 3'-RACEclone8phosphodiesterase1A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81529

About PDE1A

Primary_assembly 3: 64,747,269-65,024,874 reverse strand.mRatBN7.2:CM026976.1

This gene has 7 transcripts (splice variants), 208 orthologues, 20 paralogues and is associated with 1 phenotype. Biased expression in Testes (RPKM 227.2), Brain (RPKM 25.3) and 8 other tissues.

Summary

Enables calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP catabolic process; regulation of smooth muscle cell apoptotic process; and regulation of smooth muscle cell proliferation. Located in cytoplasm; neuronal cell body; and nucleus. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Apr 2022]

PDE1A Products (1)

mRNA Protein Name
NM_030871.1 NP_110498.1 calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
16514069 RGD
Biological Process GO Annotation Evidence References Source
involved in cGMP catabolic process IMP
IMP: Inferred from mutant phenotype
16514069 RGD
involved in regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16514069 RGD
involved in regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16514069 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
16881052 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE1A Protein Structure

PDEase_I_N

PDEase_I_N: pfam08499 (72 - 132)

PDEase_I

PDEase_I: pfam00233 (217 - 438)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 542 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

  • 3'-RACE clone 8 phosphodiesterase 1A

  • 3-RACE clone 8 phosphodiesterase 1A

  • phosphodiesterase 1A, calmodulin-dependent

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.56% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2
HY-111167 AN-2898 Inhibitor / Phase 2
HY-103493 TAK-915 Inhibitor 99.57% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136569 DSR-141562 Inhibitor 99.98% Unkown
HY-101490 PDE1-IN-2 Inhibitor 98.0% Unkown
HY-12501 ITI-214 free base Inhibitor 98.0% Unkown
HY-120741 PF-04822163 Inhibitor / Unkown
HY-120195 PF-04677490 Inhibitor / Unkown
HY-120195A PF-04827736 Inhibitor / Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-RS10208 PDE1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10209 Pde1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10210 PDE1A Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PDE1A NCBI NCBI:5136