TMX1 - thioredoxin related transmembrane protein 1 Gene

Also Known as TMX; TXNDC; PDIA11; TXNDC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81542

About TMX1

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:51,240,247-51,257,655 (from NCBI)

This gene has 3 transcripts (splice variants), 226 orthologues and 13 paralogues. Ubiquitous expression in urinary bladder (RPKM 15.6), colon (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]

TMX1 Products (1)

mRNA Protein Name
NM_030755.5 NP_110382.3 thioredoxin-related transmembrane protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables disulfide oxidoreductase activity IDA
IDA: Inferred from direct assay
11152479 GOA
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
37648867 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein disulfide isomerase activity IDA
IDA: Inferred from direct assay
29932915 GOA
enables protein-disulfide reductase activity IDA
IDA: Inferred from direct assay
22228764 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of platelet aggregation IDA
IDA: Inferred from direct assay
30425049 GOA
involved in negative regulation of triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
37648867 GOA
involved in positive regulation of ERAD pathway IDA
IDA: Inferred from direct assay
29932915 GOA
involved in regulation of calcium ion transport IDA
IDA: Inferred from direct assay
27502484 GOA
involved in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
11152479 GOA
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
37648867 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
11152479 GOA
is active in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
22045338 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMX1 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (31 - 129)

  • 0
  • 100
  • 200
  • 280 a.a.
Protein Preferred Names Protein Names

thioredoxin-related transmembrane protein 1

  • protein disulfide isomerase family A, member 11

Recombinant TMX1 Proteins

Cat. No. Product Name Accession Purity
HY-P76681 TMX1 Protein, Human (HEK293, Fc) AAH36460 (R27-S180) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153385 TMX1 Degrader 99.57% Unkown
HY-RS14779 TMX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18264 Tmx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24743 Tmx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMX1 VGNC VGNC:47643
Mus musculus TMX1 MGD MGI:1919986
Rattus norvegicus TMX1 RGD RGD:1308455
Macaca mulatta TMX1 VGNC VGNC:103880
Bos taurus TMX1 VGNC VGNC:50016
Others TMX1 NCBI