PLA2G12A - phospholipase A2 group XIIA Gene

Also Known as GXII; ROSSY; PLA2G12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81579

About PLA2G12A

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:109,709,989-109,730,070 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 11.6), prostate (RPKM 9.6) and 25 other tissues.

Summary

Secreted Phospholipase A2 (sPLA2) Enzymes liberate arachidonic acid from Phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from Other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]

PLA2G12A Products (1)

mRNA Protein Name
NM_030821.5 NP_110448.2 group XIIA secretory phospholipase A2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G12A Protein Structure

PLA2G12

PLA2G12: Group XII secretory phospholipase A2 precursor (PLA2G12) (17 - 189)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

group XIIA secretory phospholipase A2

  • GXII sPLA2

PLA2G12A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLA2G12A Q9BZM1 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
PLA2G12A Q9BZM1 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
PLA2G12A Q9BZM1 WFS1 Homo sapiens O76024
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

PLA2G12A Antibodies

Cat. No. Product Name Application Reactivity
HY-P84775 PLA2G12A Antibody (YA4472) IHC-P, FC, ELISA Human
HY-P84775A PLA2G12A Antibody (YA4472)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Coenzyme Q10 Deficiency, Primary, 9

  • COQ10D9

  • Primary Coenzyme Q10 Deficiency 9
Cerebrooculofacioskeletal Syndrome 1

  • Cofs Syndrome

  • COFS1

  • Pena-Shokeir Syndrome Type 2

  • Cofs

  • Pena-Shokeir Syndrome, Type Ii

  • Cerebrooculofacioskeletal Syndrome

  • Cerebro-Oculo-Facio-Skeletal Syndrome 1

  • Pena Shokeir Syndrome Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10617 PLA2G12A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PLA2G12A VGNC VGNC:64197
Bos taurus PLA2G12A VGNC VGNC:32954
Macaca mulatta PLA2G12A VGNC VGNC:76058
Rattus norvegicus PLA2G12A RGD RGD:1304662
Mus musculus PLA2G12A MGD MGI:1913600
Others PLA2G12A NCBI