LBH - LBH regulator of WNT signaling pathway Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81606

About LBH

Cytogenetic location: 2p23.1 Genomic coordinates (GRCh38): 2:30,231,534-30,260,028 (from NCBI)

This gene has 9 transcripts (splice variants), 190 orthologues and 1 paralogue. Broad expression in lung (RPKM 81.1), lymph node (RPKM 54.3) and 23 other tissues.

Summary

Involved in negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; and regulation of MAPK cascade. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

LBH Products (1)

mRNA Protein Name
NM_030915.4 NP_112177.2 protein LBH

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20587334 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
20587334 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17390236 GOA
involved in regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
17390236 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17390236 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17390236 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20587334 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LBH Protein Structure

Lbh

Lbh: Cardiac transcription factor regulator, Developmental protein (18 - 105)

  • 0
  • 100
  • 105 a.a.
Protein Preferred Names Protein Names

protein LBH

  • hLBH

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10224 Panobinostat 99.37% Yes
HY-10224A Panobinostat lactate 98.67% Yes

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10224R Panobinostat (Standard) 98.09% Unkown
HY-10224S Panobinostat-d4 / Unkown
HY-10224S1 Panobinostat-d4 hydrochloride / Unkown
HY-RS07542 LBH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20682 Lbh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27193 Lbh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LBH VGNC VGNC:81110
Bos taurus LBH VGNC VGNC:102824
Rattus norvegicus LBH RGD RGD:1584525
Mus musculus LBH MGD MGI:1925139