SLC25A31 - solute carrier family 25 member 31 Gene

Also Known as AAC4; ANT4; ANT 4; SFEC35kDa

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83447

About SLC25A31

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:127,730,400-127,774,292 (from NCBI)

This gene has 1 transcript (splice variant), 118 orthologues and 49 paralogues. Restricted expression toward testis (RPKM 32.1).

Summary

The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar Cytoskeleton and with glycolytic Enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

SLC25A31 Products (2)

mRNA	Protein	Name
NM_001318467.2	NP_001305396.1	ADP/ATP translocase 4 isoform 2
NM_031291.4	NP_112581.1	ADP/ATP translocase 4 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	27641616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A31 Protein Structure

Mito_carr

0
100
200
300
315 a.a.

Protein Preferred Names	Protein Names
ADP/ATP translocase 4	ADP,ATP carrier protein 4

SLC25A31 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC25A31	Q9H0C2	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	SLC25A31	Q9H0C2	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	SLC25A31	Q9H0C2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SLC25A31	Q9H0C2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Acute Laryngitis	Acute Laryngitis Nos Laryngeal Inflammation Laryngitis Nos Larynx Inflammation
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13113	SLC25A31 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC25A31	VGNC	VGNC:34757
Canis familiaris	SLC25A31	VGNC	VGNC:46305
Mus musculus	SLC25A31	MGD	MGI:1920583
Felis catus	SLC25A31	VGNC	VGNC:65269
Rattus norvegicus	SLC25A31	RGD	RGD:1596195
Macaca mulatta	SLC25A31	VGNC	VGNC:107199
Others	SLC25A31	NCBI