Jam3 - junction adhesion molecule 3 Gene

Also Known as JAM-3; JAM-C; Jcam3; 1110002N23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83964

Summary

Enables identical protein binding activity and Integrin binding activity. Involved in angiogenesis; cell-cell adhesion; and hematopoietic stem cell migration to bone marrow. Acts upstream of or within several processes, including leukocyte migration involved in inflammatory response; myeloid progenitor cell differentiation; and regulation of actin Cytoskeleton organization by cell-cell adhesion. Located in Schmidt-Lanterman incisure; bicellular tight junction; and paranodal junction. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human JAM3 (junctional adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]

Jam3 Products (1)

mRNA Protein Name
NM_023277.4 NP_075766.1 junctional adhesion molecule C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16093349 MGI
enables integrin binding IPI
IPI: Inferred from physical interaction
16093349 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16093349 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adaptive immune response IMP
IMP: Inferred from mutant phenotype
19342649 MGI
involved in angiogenesis IDA
IDA: Inferred from direct assay
15994945 MGI
acts upstream of or within cell adhesion IGI
IGI: Inferred from genetic interaction
16093349 MGI
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
16093349 MGI
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
17099249 MGI
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24357068 MGI
acts upstream of or within cell-matrix adhesion IDA
IDA: Inferred from direct assay
17099249 MGI
acts upstream of or within cell-matrix adhesion IGI
IGI: Inferred from genetic interaction
17099249 MGI
acts upstream of or within establishment of cell polarity IDA
IDA: Inferred from direct assay
17099249 MGI
involved in hematopoietic stem cell migration to bone marrow IMP
IMP: Inferred from mutant phenotype
24357068 MGI
acts upstream of or within leukocyte migration involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
15879142 MGI
acts upstream of or within myelination IMP
IMP: Inferred from mutant phenotype
18048693 MGI
acts upstream of or within myeloid progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
19109565 MGI
acts upstream of or within neutrophil homeostasis IMP
IMP: Inferred from mutant phenotype
17455169 MGI
acts upstream of or within regulation of actin cytoskeleton organization by cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15372036 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
15372036 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
15372036 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
18048693 MGI
Cellular Component GO Annotation Evidence References Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
21097846 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
17853450 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
15372036 MGI
located in paranodal junction IDA
IDA: Inferred from direct assay
18048693 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

junctional adhesion molecule C

  • junction cell adhesion molecule 3

  • junction cell adhesion molecule C

  • junctional adhesion molecule 3

Recombinant Jam3 Proteins

Cat. No. Product Name Accession Purity
HY-P73849 JAM-C/CD323 Protein, Mouse (HEK293, His) Q9D8B7/NP_075766.1 (E30-N241) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07028 JAM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19344 Jam3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25835 Jam3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jam3 NCBI NCBI:83700