GTF2IRD2 - GTF2I repeat domain containing 2 Gene

Also Known as FP630; GTF2IRD2A; GTF2IRD2 alpha

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 84163

Summary

This gene is one of several closely related genes on chromosome 7 encoding proteins containing helix-loop-helix motifs. These proteins may function as regulators of transcription. The encoded protein is unique in that its C-terminus is derived from CHARLIE8 transposable element sequence. This gene is located in a region of chromosome 7 that is deleted in Williams-Beuren syndrome, and loss of this locus may contribute to the cognitive phenotypes observed in this disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GTF2IRD2 Products (1)

mRNA Protein Name
NM_001388086.1 NP_001375015.1 general transcription factor II-I repeat domain-containing protein 2A isoform 11

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

general transcription factor II-I repeat domain-containing protein 2A

  • GTF2I repeat domain-containing protein 2, alpha

  • GTF2I repeat domain-containing protein 2A

  • general transcription factor II i repeat domain 2 alpha

  • transcription factor GTF2IRD2-alpha

GTF2IRD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GTF2IRD2 Q86UP8 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra
GTF2IRD2 Q86UP8 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05904 GTF2IRD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown