CAMKK1 - calcium/calmodulin dependent protein kinase kinase 1 Gene

Also Known as CAMKKA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84254

About CAMKK1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:3,860,315-3,893,053 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 22 paralogues. Broad expression in brain (RPKM 12.8), salivary gland (RPKM 4.6) and 24 other tissues.

Summary

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the CA(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CAMKK1 Products (3)

mRNA Protein Name
NM_032294.3 NP_115670.1 calcium/calmodulin-dependent protein kinase kinase 1 isoform a
NM_172206.2 NP_757343.2 calcium/calmodulin-dependent protein kinase kinase 1 isoform c
NM_172207.3 NP_757344.2 calcium/calmodulin-dependent protein kinase kinase 1 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18242179 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMKK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (128 - 409)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase kinase 1

  • CAMKK alpha protein

CAMKK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAMKK1 Q8N5S9 YWHAH Homo sapiens Q04917
Pull Down
32707033
Intra
CAMKK1 Q8N5S9 YWHAE Homo sapiens P62258
Pull Down
32707033
Intra
CAMKK1 Q8N5S9 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tracheitis

  • Acute Tracheitis

  • Chronic Tracheitis

  • Bacterial Tracheitis

  • Acute Tracheitis Nos

  • Tracheitis Nos

  • Tracheal Inflammation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS01865 CAMKK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21829 Camkk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28346 Camkk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CAMKK1 VGNC VGNC:60336
Bos taurus CAMKK1 VGNC VGNC:26725
Rattus norvegicus CAMKK1 RGD RGD:62023
Mus musculus CAMKK1 MGD MGI:1891766
Canis familiaris CAMKK1 VGNC VGNC:38683
Macaca mulatta CAMKK1 VGNC VGNC:99125
Others CAMKK1 NCBI