ZNF282 - zinc finger protein 282 Gene

Also Known as HUB1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8427

About ZNF282

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:149,195,546-149,226,243 (from NCBI)

This gene has 4 transcripts (splice variants), 393 orthologues and 36 paralogues. Ubiquitous expression in endometrium (RPKM 6.2), prostate (RPKM 5.8) and 25 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF282 Products (2)

mRNA Protein Name
NM_001303481.3 NP_001290410.1 zinc finger protein 282 isoform 2
NM_003575.4 NP_003566.1 zinc finger protein 282 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF282 Protein Structure

DUF3669

DUF3669: Zinc finger protein (93 - 170)

KRAB

KRAB: KRAB box (198 - 238)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (534 - 556)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (561 - 584)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (588 - 611)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (616 - 640)

  • 0
  • 200
  • 400
  • 600
  • 671 a.a.
Protein Preferred Names Protein Names

zinc finger protein 282

  • HTLV-I U5 repressive element-binding protein 1

ZNF282 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF282 Q9UDV7 ZNF398 Homo sapiens Q8TD17
Anti Tag CoIP
31403225
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16121 ZNF282 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZNF282 MGD MGI:2141413
Rattus norvegicus ZNF282 RGD RGD:1306278
Others ZNF282 NCBI