CHCHD6 - coiled-coil-helix-coiled-coil-helix domain containing 6 Gene

Also Known as CHCM1; Mic25; MICOS25; PPP1R23

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84303

About CHCHD6

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:126,704,240-126,960,420 (from NCBI)

This gene has 8 transcripts (splice variants), 218 orthologues and 1 paralogue. Broad expression in testis (RPKM 1.6), brain (RPKM 0.9) and 25 other tissues.

Summary

Involved in cellular response to DNA damage stimulus and cristae formation. Located in cytosol and mitochondrial inner membrane. Part of MICOS complex. [provided by Alliance of Genome Resources, Apr 2022]

CHCHD6 Products (2)

mRNA Protein Name
NM_001320610.2 NP_001307539.1 MICOS complex subunit MIC25 isoform 1
NM_032343.3 NP_115719.1 MICOS complex subunit MIC25 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22228767 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
22228767 GOA
involved in cristae formation IMP
IMP: Inferred from mutant phenotype
22228767 GOA
Cellular Component GO Annotation Evidence References Source
part of MICOS complex IDA
IDA: Inferred from direct assay
25781180 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
22228767 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
25781180 GOA
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
22228767 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHCHD6 Protein Structure

DUF737

DUF737: Protein of unknown function (DUF737) (16 - 189)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

MICOS complex subunit MIC25

  • coiled coil helix cristae morphology 1

CHCHD6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHCHD6 Q9BRQ6 SAMM50 Homo sapiens Q9Y512
Y2H Array
32296183
Intra
CHCHD6 Q9BRQ6 SAMM50 Homo sapiens Q9Y512
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 37

  • COXPD37
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS02603 CHCHD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CHCHD6 VGNC VGNC:60841
Macaca mulatta CHCHD6 VGNC VGNC:71119
Bos taurus CHCHD6 VGNC VGNC:27274
Mus musculus CHCHD6 MGD MGI:1913348
Rattus norvegicus CHCHD6 RGD RGD:1304561
Others CHCHD6 NCBI