PSRC1 - proline and serine rich coiled-coil 1 Gene

Also Known as DDA3; FP3214

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84722

About PSRC1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,279,556-109,283,145 (from NCBI)

This gene has 12 transcripts (splice variants), 106 orthologues and 1 paralogue. Broad expression in brain (RPKM 9.0), testis (RPKM 4.6) and 23 other tissues.

Summary

This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in Mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

PSRC1 Products (14)

mRNA Protein Name
NM_001005290.4 NP_001005290.1 proline/serine-rich coiled-coil protein 1 isoform b
NM_001032291.3 NP_001027462.1 proline/serine-rich coiled-coil protein 1 isoform a
NM_001350237.2 NP_001337166.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350238.2 NP_001337167.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350239.2 NP_001337168.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350240.2 NP_001337169.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350241.2 NP_001337170.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001350242.2 NP_001337171.1 proline/serine-rich coiled-coil protein 1 isoform d
NM_001363309.2 NP_001350238.1 proline/serine-rich coiled-coil protein 1 isoform c
NM_001394002.1 NP_001380931.1 proline/serine-rich coiled-coil protein 1 isoform a
NM_001394003.1 NP_001380932.1 proline/serine-rich coiled-coil protein 1 isoform b
NM_001394004.1 NP_001380933.1 proline/serine-rich coiled-coil protein 1 isoform b
NM_001394005.1 NP_001380934.1 proline/serine-rich coiled-coil protein 1 isoform c
NM_032636.8 NP_116025.1 proline/serine-rich coiled-coil protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18411309 GOA
Biological Process GO Annotation Evidence References Source
involved in mitotic metaphase chromosome alignment IDA
IDA: Inferred from direct assay
18411309 GOA
involved in regulation of mitotic spindle organization IDA
IDA: Inferred from direct assay
18411309 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
18411309 GOA
colocalizes with spindle microtubule IDA
IDA: Inferred from direct assay
18411309 GOA
colocalizes with spindle pole IDA
IDA: Inferred from direct assay
18411309 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSRC1 Protein Structure

GTSE1_N

GTSE1_N: G-2 and S-phase expressed 1 (7 - 104)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
Protein Preferred Names Protein Names

proline/serine-rich coiled-coil protein 1

  • differential display and activated by p53

PSRC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSRC1 Q6PGN9 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pulmonary Embolism And Infarction
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11343 PSRC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PSRC1 VGNC VGNC:33484
Felis catus PSRC1 VGNC VGNC:64418
Canis familiaris PSRC1 VGNC VGNC:45125
Rattus norvegicus PSRC1 RGD RGD:1585037
Macaca mulatta PSRC1 VGNC VGNC:76307
Mus musculus PSRC1 MGD MGI:1913099
Others PSRC1 NCBI