UNC119B - unc-119 lipid binding chaperone B Gene

Also Known as POC7B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84747

About UNC119B

This gene has 3 transcripts (splice variants), 267 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 22.0), ovary (RPKM 19.5) and 24 other tissues.

Summary

Enables lipid binding activity. Involved in cilium assembly and lipoprotein transport. Located in ciliary transition zone. [provided by Alliance of Genome Resources, Apr 2022]

UNC119B Products (1)

mRNA Protein Name
NM_001080533.3 NP_001074002.1 protein unc-119 homolog B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipid binding IDA
IDA: Inferred from direct assay
22085962 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22085962 GOA
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
22085962 GOA
involved in lipoprotein transport IDA
IDA: Inferred from direct assay
22085962 GOA
Cellular Component GO Annotation Evidence References Source
located in ciliary transition zone IDA
IDA: Inferred from direct assay
22085962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC119B Protein Structure

GMP_PDE_delta

GMP_PDE_delta: GMP-PDE, delta subunit (86 - 248)

  • 0
  • 100
  • 200
  • 251 a.a.
Protein Preferred Names Protein Names

protein unc-119 homolog B

  • POC7 centriolar protein homolog B

UNC119B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UNC119B A6NIH7 NPHP3 Homo sapiens Q7Z494
FPS
22960633
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Macular Degeneration, X-Linked Atrophic

  • X-Linked Atrophic Macular Degeneration

  • Macular Degeneration, X-Linked, Atrophic

  • MDXLA

  • Degeneration, Macular, X-Linked Atrophic
Joubert Syndrome 22

  • JBTS22

  • Joubert Syndrome, Type 22
Retinitis Pigmentosa 2

  • RP2

  • X-Linked Retinitis Pigmentosa 2

  • Xlrp2

  • Xlrp-2

  • Retinitis Pigmentosa-2

  • Retinitis Pigmentosa, Type 2
Nephronophthisis 2

  • NPHP2

  • Nph2

  • Nephronophthisis 2, Infantile

  • Infantile Nephronophthisis 2

  • Infantile Nephronophthisis

  • Nephronophthisis, Type 2
Nephronophthisis

  • Medullary Cystic Disease

  • Medullary Cystic Kidney

  • Nph

  • Nphp

  • Kidney Disease, Cystic, Medullary
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164368 GLUT4 activator 2 Activator / Unkown
HY-RS15463 UNC119B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus UNC119B VGNC VGNC:66821
Rattus norvegicus UNC119B RGD RGD:1309359
Mus musculus UNC119B MGD MGI:2147162
Bos taurus UNC119B VGNC VGNC:36663
Canis familiaris UNC119B VGNC VGNC:48134
Others UNC119B NCBI