TXNDC17 - thioredoxin domain containing 17 Gene

Also Known as TRP14; TXNL5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84817

About TXNDC17

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:6,641,060-6,644,541 (from NCBI)

This gene has 10 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in colon (RPKM 14.3), esophagus (RPKM 13.2) and 25 other tissues.

Summary

Enables peroxidase activity and protein-disulfide reductase (NAD(P)) activity. Involved in tumor necrosis factor-mediated signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

TXNDC17 Products (1)

mRNA Protein Name
NM_032731.4 NP_116120.1 thioredoxin domain-containing protein 17

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables peroxidase activity IDA
IDA: Inferred from direct assay
14607844 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14607844 GOA
enables protein-disulfide reductase (NAD(P)H) activity IDA
IDA: Inferred from direct assay
14607844 GOA
Biological Process GO Annotation Evidence Références Source
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
14607844 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytosol IDA
IDA: Inferred from direct assay
14607844 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin domain-containing protein 17

  • 14 kDa thioredoxin-related protein

TXNDC17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TXNDC17 Q9BRA2 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
TXNDC17 Q9BRA2 EXOSC8 Homo sapiens Q96B26
Validated Y2H
25416956
Intra
TXNDC17 Q9BRA2 EXOSC8 Homo sapiens Q96B26
Y2H Array
25416956
Intra
TXNDC17 Q9BRA2 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
TXNDC17 Q9BRA2 RUFY1 Homo sapiens Q96T51
Validated Y2H
25416956
Intra
TXNDC17 Q9BRA2 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
TXNDC17 Q9BRA2 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
TXNDC17 Q9BRA2 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Parametritis

  • Pelvic Cellulitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15293 TXNDC17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20659 Txndc17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27170 Txndc17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TXNDC17 VGNC VGNC:36538
Mus musculus TXNDC17 MGD MGI:1289248
Felis catus TXNDC17 VGNC VGNC:66728
Macaca mulatta TXNDC17 VGNC VGNC:104669
Rattus norvegicus TXNDC17 RGD RGD:1308868
Others TXNDC17 NCBI