RTCA - RNA 3'-terminal phosphate cyclase Gene

Also Known as RPC; RTC1; RTCD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8634

About RTCA

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,266,216-100,292,769 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 10.7), kidney (RPKM 10.6) and 25 other tissues.

Summary

This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

RTCA Products (2)

mRNA Protein Name
NM_001130841.2 NP_001124313.1 RNA 3'-terminal phosphate cyclase isoform a
NM_003729.4 NP_003720.1 RNA 3'-terminal phosphate cyclase isoform b

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA-3'-phosphate cyclase activity IDA
IDA: Inferred from direct assay
9184239 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleoplasm IDA
IDA: Inferred from direct assay
9184239 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTCA Protein Structure

RTC

RTC: RNA 3'-terminal phosphate cyclase (8 - 339)

RTC_insert

RTC_insert: RNA 3'-terminal phosphate cyclase (RTC), insert domain (184 - 288)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

RNA 3'-terminal phosphate cyclase

  • RNA terminal phosphate cyclase domain 1

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group C

  • Fanconi Anemia Complementation Group C

  • FANCC

  • Facc

  • Fac

  • Fa3

  • Fanconi Pancytopenia Type 3

  • Fanconi Pancytopenia, Type 3

  • Faces Syndrome

  • Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

  • Friedman-Goodman Syndrome

  • Abnormality Of The Face
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12315 RTCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RTCA VGNC VGNC:64804
Bos taurus RTCA VGNC VGNC:34193
Macaca mulatta RTCA VGNC VGNC:77043
Canis familiaris RTCA VGNC VGNC:54065
Mus musculus RTCA MGD MGI:1913618
Rattus norvegicus RTCA RGD RGD:1303111
Others RTCA NCBI