CCN4 - cellular communication network factor 4 Gene

Also Known as WISP1; WISP1c; WISP1i; WISP1tc; WISP1-OT1; WISP1-UT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8840

About CCN4

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:133,191,039-133,231,690 (from NCBI)

This gene has 5 transcripts (splice variants), 230 orthologues and 5 paralogues. Broad expression in endometrium (RPKM 7.1), adrenal (RPKM 6.0) and 17 other tissues.

Summary

This gene encodes a member of the Wnt1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. Wnt1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the Wnt1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated Apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]

CCN4 Products (4)

mRNA	Protein	Name
NM_001204869.2	NP_001191798.1	CCN family member 4 isoform 3 precursor
NM_001204870.2	NP_001191799.1	CCN family member 4 isoform 4 precursor
NM_003882.4	NP_003873.1	CCN family member 4 isoform 1 precursor
NM_080838.3	NP_543028.1	CCN family member 4 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11598131	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	25281430	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20684029	GOA
involved in regulation of cytokine production	IDA IDA: Inferred from direct assay	25281430	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	25281430	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCN4 Protein Structure

IGFBP

VWC

TSP_1

Cys_knot

0
100
200
300
367 a.a.

Protein Preferred Names	Protein Names
CCN family member 4	WISP1 3'UTR-associated RNA 1

CCN4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCN4	O95388	OTX1	Homo sapiens	P32242	Validated Y2H	32296183
Intra	CCN4	O95388	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	CCN4	O95388	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	CCN4	O95388	HOXA1	Homo sapiens	P49639	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCN4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77284	WISP1/CCN4 Protein, Human (HEK293, His)	O95388 (T23-N367)	≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Bladder Transitional Cell Papilloma	Bladder Papilloma Transitional Cell Papilloma Of Bladder Urinary Bladder Urothelial Papilloma Urothelial Papilloma Bladder Urothelial Papilloma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02113	CCN4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17581	Ccn4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24041	Ccn4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CCN4	VGNC	VGNC:36944
Macaca mulatta	CCN4	VGNC	VGNC:70706
Rattus norvegicus	CCN4	RGD	RGD:69431
Mus musculus	CCN4	MGD	MGI:1197008
Canis familiaris	CCN4	VGNC	VGNC:48414
Felis catus	CCN4	VGNC	VGNC:60547
Others	CCN4	NCBI