Tek - TEK receptor tyrosine kinase Gene

Also Known as Tie2; Tie-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89804

Summary

Enables growth factor binding activity. Involved in several processes, including endochondral ossification; response to cAMP; and response to estrogen. Predicted to be located in several cellular components, including basolateral plasma membrane; centriolar satellite; and microvillus. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Predicted to colocalize with actin filament and stress fiber. Biomarker of several diseases, including acute kidney tubular necrosis; brain ischemia; gastric ulcer; goiter; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Tek Products (1)

mRNA Protein Name
NM_001105737.1 NP_001099207.1 angiopoietin-1 receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables growth factor binding IPI
IPI: Inferred from physical interaction
15714275 RGD
Biological Process GO Annotation Evidence References Source
involved in endochondral ossification IEP
IEP: Inferred from expression pattern
11735002 RGD
involved in glomerulus vasculature development IMP
IMP: Inferred from mutant phenotype
20056745 RGD
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
9329972 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
11397875 RGD
involved in response to estrogen IDA
IDA: Inferred from direct assay
11856554 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
11504684 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15945074 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiopoietin-1 receptor

  • TEK tyrosine kinase, endothelial

  • endothelial-specific receptor tyrosine kinase

  • tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2

Recombinant Tek Proteins

Cat. No. Product Name Accession Purity
HY-P73438 TIE-2 Protein, Rat (HEK293, Fc) NP_001099207.1 (A23-L743) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15514 Merestinib Inhibitor 99.99% Yes
HY-RS14355 TEK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18596 Tek Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25081 Tek Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tek NCBI NCBI:7010