Prmt3 - protein arginine methyltransferase 3 Gene

Also Known as Hrmt1l3

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 89820

About Prmt3

Primary_assembly 1: 99,492,724-99,579,435 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 205 orthologues, 10 paralogues and is associated with 2 phenotypes. Biased expression in Muscle (RPKM 111.1), Spleen (RPKM 18.2) and 9 other tissues.

Summary

Enables modified amino acid binding activity and protein-arginine omega-N asymmetric methyltransferase activity. Involved in dendritic spine morphogenesis and peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in cytoplasm. Biomarker of asthma. Orthologous to human PRMT3 (protein arginine methyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]

Prmt3 Products (1)

mRNA	Protein	Name
NM_053557.1	NP_446009.1	protein arginine N-methyltransferase 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables modified amino acid binding	IDA IDA: Inferred from direct assay	10899106	RGD
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	9642256	RGD
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA IDA: Inferred from direct assay	9642256	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	20647003	RGD
involved in peptidyl-arginine methylation	IDA IDA: Inferred from direct assay	10899106	RGD
involved in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IDA IDA: Inferred from direct assay	9642256	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt3 Protein Structure

AdoMet_MTases

0
100
200
300
400
500
528 a.a.

Protein Preferred Names	Protein Names
protein arginine N-methyltransferase 3	heterogeneous nuclear ribonucleoprotein methyltransferase-like 3 heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 protein arginine N-methyltransferase 3(hnRNP methyltransferase S. cerevisiae)-like 3

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128717A	GSK3368715 dihydrochloride	Inhibitor	99.96%	Phase 1
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.93%	Unkown
HY-19715	SGC707	Inhibitor	99.99%	Unkown
HY-128717	GSK3368715	Inhibitor	99.41%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.68%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown
HY-110158	UNC2327	Inhibitor	99.70%	Unkown
HY-171132	PRMT3-IN-5	Inhibitor	/	Unkown
HY-159728	PROTAC PRMT3 degrader 1	Degrader	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-159732	PRMT3-IN-4	Inhibitor	/	Unkown
HY-175821	PRMT1-IN-3	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prmt3	NCBI	NCBI:10196