DCAF15 - DDB1 and CUL4 associated factor 15 Gene

Also Known as C19orf72

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90379

About DCAF15

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:13,952,509-13,961,449 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 177 orthologues. Broad expression in testis (RPKM 20.9), bone marrow (RPKM 11.3) and 24 other tissues.

Summary

Enables small molecule binding activity. Involved in protein polyubiquitination and regulation of natural killer cell activation. Part of Cul4-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DCAF15 Products (9)

mRNA Protein Name
NM_001393637.1 NP_001380566.1 DDB1- and CUL4-associated factor 15 isoform 2
NM_001393638.1 NP_001380567.1 DDB1- and CUL4-associated factor 15 isoform 3
NM_001393639.1 NP_001380568.1 DDB1- and CUL4-associated factor 15 isoform 4
NM_001393640.1 NP_001380569.1 DDB1- and CUL4-associated factor 15 isoform 5
NM_001393641.1 NP_001380570.1 DDB1- and CUL4-associated factor 15 isoform 6
NM_001393642.1 NP_001380571.1 DDB1- and CUL4-associated factor 15 isoform 7
NM_001393643.1 NP_001380572.1 DDB1- and CUL4-associated factor 15 isoform 8
NM_001393644.1 NP_001380573.1 DDB1- and CUL4-associated factor 15 isoform 9
NM_138353.4 NP_612362.2 DDB1- and CUL4-associated factor 15 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16949367 GOA
enables small molecule binding IPI
IPI: Inferred from physical interaction
28302793 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
28302793 GOA
involved in regulation of natural killer cell activation IMP
IMP: Inferred from mutant phenotype
31452512 GOA
Cellular Component GO Annotation Evidence Références Source
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16949367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCAF15 Protein Structure

DCAF15_WD40

DCAF15_WD40: DDB1-and CUL4-substrate receptor 15, WD repeat (47 - 260)

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  • 600 a.a.
Protein Preferred Names Protein Names

DDB1- and CUL4-associated factor 15

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-13650 Indisulam Inhibitor 99.80% Phase 2
HY-14571 E7820 Inhibitor 99.26% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-153459 IBG1 Degrader 99.88% Unkown
HY-W037495 DCAF15 ligand-1 99.32% Unkown
HY-W133627 dCeMM1 99.53% Unkown
HY-149441 Indisulam analog-1 / Unkown
HY-162411 E3 ligase Ligand 24 / Unkown
HY-173274 CB039 98.10% Unkown
HY-177779 dRRM-1 / Unkown
HY-183755 YSA64 / Unkown
HY-RS03561 DCAF15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18306 Dcaf15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24784 Dcaf15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DCAF15 VGNC VGNC:71706
Rattus norvegicus DCAF15 RGD RGD:1304881
Mus musculus DCAF15 MGD MGI:2684420
Canis familiaris DCAF15 VGNC VGNC:39792
Felis catus DCAF15 VGNC VGNC:61356
Bos taurus DCAF15 VGNC VGNC:27902
Others DCAF15 NCBI