2. Gene
  3. PRMT9 - protein arginine methyltransferase 9 Gene

PRMT9 - protein arginine methyltransferase 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PRMT10

Gene ID: 90826 | Gene type: protein coding

About PRMT9

Cytogenetic location: 4q31.23 Genomic coordinates (GRCh38): 4:147,637,785-147,684,163 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in adrenal (RPKM 9.7), thyroid (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017]

PRMT9 Products(6)

mRNA Protein Name
NM_001304458.2 NP_001291387.1 protein arginine N-methyltransferase 9 isoform 2
NM_001350141.2 NP_001337070.1 protein arginine N-methyltransferase 9 isoform 3
NM_001350142.2 NP_001337071.1 protein arginine N-methyltransferase 9 isoform 2
NM_001350143.2 NP_001337072.1 protein arginine N-methyltransferase 9 isoform 5
NM_001350144.2 NP_001337073.1 protein arginine N-methyltransferase 9 isoform 6
NM_138364.4 NP_612373.2 protein arginine N-methyltransferase 9 isoform 1

PRMT9 Protein Structure

TPR_2

TPR_2: Tetratricopeptide repeat (104 - 133)

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (175 - 235)

  • 0
  • 200
  • 400
  • 600
  • 845 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 9

protein arginine N-methyltransferase 10

Related Diseases

Diseases Alias
Mandibulofacial Dysostosis With Alopecia

MFDA
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-155814 EML734 Inhibitor / Unkown
HY-RS11186 PRMT9 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRMT9 MGD MGI:2142651
Rattus norvegicus PRMT9 RGD RGD:1306157
Macaca mulatta PRMT9 VGNC VGNC:76313
Bos taurus PRMT9 VGNC VGNC:33354
Canis familiaris PRMT9 VGNC VGNC:45002
Felis catus PRMT9 VGNC VGNC:64363