EIF1AY - eukaryotic translation initiation factor 1A Y-linked Gene

Also Known as eIF-4C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9086

About EIF1AY

Cytogenetic location: Yq11.223 Genomic coordinates (GRCh38): Y:20,575,776-20,593,154 (from NCBI)

This gene has 5 transcripts (splice variants), 221 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 13.9), prostate (RPKM 13.1) and 20 other tissues.

Summary

This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

EIF1AY Products (2)

mRNA Protein Name
NM_001278612.2 NP_001265541.1 eukaryotic translation initiation factor 1A, Y-chromosomal isoform 2
NM_004681.4 NP_004672.2 eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF1AY Protein Structure

eIF-1a

eIF-1a: Translation initiation factor 1A / IF-1 (30 - 94)

  • 0
  • 100
  • 144 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 1A, Y-chromosomal

  • eukaryotic translation initiation factor 1A, Y chromosome

EIF1AY Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF1AY O14602 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
EIF1AY O14602 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
EIF1AY O14602 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
EIF1AY O14602 EIF5B Homo sapiens O60841
NMR
12569173
Intra
EIF1AY O14602 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
EIF1AY O14602 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
EIF1AY O14602 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
EIF1AY O14602 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04239 EIF1AY Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20152 Eif1ax Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26656 Eif1ax Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EIF1AY RGD RGD:1306331
Mus musculus EIF1AY MGD MGI:1913485