IDI2 - isopentenyl-diphosphate delta isomerase 2 Gene

Also Known as IPPI2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91734

About IDI2

Cytogenetic location: 10p15.3 Genomic coordinates (GRCh38): 10:1,018,910-1,025,859 (from NCBI)

This gene has 1 transcript (splice variant), 149 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 2.6), thyroid (RPKM 1.6) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of Cholesterol and Other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]

IDI2 Products (1)

mRNA Protein Name
NM_033261.3 NP_150286.1 isopentenyl-diphosphate delta-isomerase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables isopentenyl-diphosphate delta-isomerase activity IDA
IDA: Inferred from direct assay
17202134 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within isopentenyl diphosphate metabolic process IDA
IDA: Inferred from direct assay
17202134 GOA
involved in isoprenoid biosynthetic process IDA
IDA: Inferred from direct assay
17202134 GOA
Cellular Component GO Annotation Evidence References Source
located in peroxisome IDA
IDA: Inferred from direct assay
17202134 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IDI2 Protein Structure

NUDIX

NUDIX: NUDIX domain (51 - 198)

  • 0
  • 100
  • 200
  • 227 a.a.
Protein Preferred Names Protein Names

isopentenyl-diphosphate delta-isomerase 2

  • IPP isomerase 2

IDI2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IDI2 Q9BXS1 LDB1 Homo sapiens Q86U70-2
Y2H Array
32296183
Intra
IDI2 Q9BXS1 LDB1 Homo sapiens Q86U70-2
Anti Tag CoIP
28514442
Intra
IDI2 Q9BXS1 LDB1 Homo sapiens Q86U70-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IDI2 Proteins

Cat. No. Product Name Accession Purity
HY-P70903 IDI2 Protein, Human (His, solution) Q9BXS1 (M1-V227) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70903A IDI2 Protein, Human (C-His) Q9BXS1 (D3-V227) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06537 IDI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126926 5-Deaza-FMN / Unkown
HY-RS21356 Idi2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27875 Idi2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IDI2 RGD RGD:1559783
Mus musculus IDI2 MGD MGI:2444315
Others IDI2 NCBI