DNER - delta/notch like EGF repeat containing Gene

Also Known as bet; UNQ26

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92737

About DNER

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:229,357,629-229,714,555 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 5 paralogues. Biased expression in brain (RPKM 69.6), adrenal (RPKM 34.4) and 2 other tissues.

Summary

Predicted to enable Notch binding activity. Involved in central nervous system development. Located in dendrite; early endosome; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

DNER Products (1)

mRNA Protein Name
NM_139072.4 NP_620711.3 delta and Notch-like epidermal growth factor-related receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11950833 GOA
Biological Process GO Annotation Evidence References Source
involved in central nervous system development IEP
IEP: Inferred from expression pattern
11950833 GOA
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
11950833 GOA
located in early endosome IDA
IDA: Inferred from direct assay
11950833 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11950833 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNER Protein Structure

EGF

EGF: EGF-like domain (98 - 131)

EGF

EGF: EGF-like domain (353 - 387)

EGF

EGF: EGF-like domain (399 - 424)

EGF

EGF: EGF-like domain (434 - 464)

EGF

EGF: EGF-like domain (472 - 500)

EGF

EGF: EGF-like domain (509 - 538)

hEGF

hEGF: Human growth factor-like EGF (566 - 578)

EGF

EGF: EGF-like domain (585 - 614)

  • 0
  • 200
  • 400
  • 600
  • 737 a.a.
Protein Preferred Names Protein Names

delta and Notch-like epidermal growth factor-related receptor

  • H_NH0150O02.1

DNER Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DNER Q8NFT8 PDLIM7 Homo sapiens Q9NR12
Y2H Prey Pooling
32296183
Intra
DNER Q8NFT8 PDLIM7 Homo sapiens Q9NR12
Validated Y2H
32296183
Intra
DNER Q8NFT8 PDLIM7 Homo sapiens Q9NR12
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Complement Component 7 Deficiency

  • C7 Deficiency

  • C7D
Autoimmune Epilepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03900 DNER Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20716 Dner Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27227 Dner Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DNER MGD MGI:2152889
Bos taurus DNER VGNC VGNC:28139
Macaca mulatta DNER VGNC VGNC:71895
Felis catus DNER VGNC VGNC:61557
Canis familiaris DNER VGNC VGNC:40029
Rattus norvegicus DNER RGD RGD:1359385
Others DNER NCBI