GPR55 - G protein-coupled receptor 55 Gene

Also Known as LPIR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9290

About GPR55

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:230,907,328-230,961,201 (from NCBI)

This gene has 6 transcripts (splice variants), 182 orthologues and 16 paralogues. Biased expression in testis (RPKM 2.7), spleen (RPKM 2.0) and 13 other tissues.

Summary

This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely Cannabinoid Receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]

GPR55 Products (4)

mRNA Protein Name
NM_005683.4 NP_005674.2 G-protein coupled receptor 55
XM_011512176.3 XP_011510478.1 G-protein coupled receptor 55 isoform X1
XM_005246952.5 XP_005247009.1 G-protein coupled receptor 55 isoform X1
XM_011512175.4 XP_011510477.1 G-protein coupled receptor 55 isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cannabinoid receptor activity IDA
IDA: Inferred from direct assay
19723626 GOA
Biological Process GO Annotation Evidence References Source
involved in bone resorption IDA
IDA: Inferred from direct assay
19805329 GOA
involved in negative regulation of osteoclast differentiation IDA
IDA: Inferred from direct assay
19805329 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
18757503 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
19805329 GOA
involved in positive regulation of Rho protein signal transduction IDA
IDA: Inferred from direct assay
19805329 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
18757503 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR55 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (38 - 288)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 55

Related Diseases

Diseases Alias
Lennox-Gastaut Syndrome

  • Epileptic Encephalopathy Lennox-Gastaut Type

  • Lennox Syndrome

  • Encephalopathy Of Childhood

  • Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

  • Lgs
Vulvar Syringoma
Cannabis Abuse

  • Marijuana Abuse
Cannabis Dependence

  • Marijuana Abuse

  • Cannabinoid Addiction

  • Cannabinoid Dependence

  • Cannabis Addiction
Childhood Electroclinical Syndrome
Hallucinogen Dependence

  • Hallucinogen Addiction
Dravet Syndrome

  • Severe Myoclonic Epilepsy Of Infancy

  • Smei

  • Severe Myoclonic Epilepsy In Infancy

  • Epileptic Encephalopathy, Early Infantile, 6

  • DRVT

  • Developmental And Epileptic Encephalopathy 6a

  • Dee6a

  • Eiee6

  • Dee6

  • Developmental And Epileptic Encephalopathy 6

  • Early Infantile Epileptic Encephalopathy 6

  • Myoclonic Epilepsy, Severe, Of Infancy

  • Sme

  • Severe Myoclonus Epilepsy Of Infancy

  • Borderline Smei

  • Smeb

  • Smeb-M

  • Smeb-O

  • Smeb-Sw

  • Smei-Borderland

  • Smei-Borderland More Than One Feature

  • Smei-Borderland-Myoclonic Seizures

  • Smei-Borderland-Spike Wave

  • Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures

  • ICEGTC

  • Developmental And Epileptic Encephalopathy, 6

  • Infantile Severe Myoclonic Epilepsy

  • Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Developmental And Epileptic Encephalopathy

  • Encephalopathy, Developmental And Epileptic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10863 Anandamide Activator ≥99.0% Unkown
HY-16697 CID 16020046 Antagonist 99.81% Unkown
HY-107541 O-1602 Agonist 99.68% Unkown
HY-110125 ML-193 Antagonist 99.82% Unkown
HY-116637 Tetrahydromagnolol Antagonist 99.89% Unkown
HY-116461 ML-184 Agonist 99.57% Unkown
HY-W020035 L-α-lysophosphatidylinositol (Soy) sodium 99.96% Unkown
HY-111083 ML191 Antagonist 99.81% Unkown
HY-156157 GPR55 agonist 4 Agonist 98.36% Unkown
HY-10863S Anandamide-d8 Activator 99.90% Unkown
HY-122246 ML192 Antagonist 99.70% Unkown
HY-156107 GPR55 agonist 3 Agonist 99.17% Unkown
HY-125111 PSB-SB-487 Antagonist 98.01% Unkown
HY-123239 KLS-13019 Antagonist 98.03% Unkown
HY-10863S1 Anandamide-d11 99% Unkown
HY-150187 20:4 Lyso PI Agonist / Unkown
HY-10863S2 Anandamide-15N / Unkown
HY-P11264 Cyclic peptide P1-1 Antagonist / Unkown
HY-114954 CID1792197 Agonist / Unkown
HY-103336 Tocrifluor 1117 Agonist / Unkown
HY-123302 CID1172084 Agonist / Unkown
HY-W1058476 GPR35 agonist 6 Inhibitor / Unkown
HY-111162 GSK494581A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GPR55 VGNC VGNC:104534
Canis familiaris GPR55 VGNC VGNC:41438
Mus musculus GPR55 MGD MGI:2685064
Bos taurus GPR55 VGNC VGNC:29591
Felis catus GPR55 VGNC VGNC:67433
Rattus norvegicus GPR55 RGD RGD:1559828
Others GPR55 NCBI