OLFM2 - olfactomedin 2 Gene

Also Known as NOE2; OlfC; NOELIN2; NOELIN2_V1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93145

About OLFM2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:9,853,718-9,936,515 (from NCBI)

This gene has 5 transcripts (splice variants), 252 orthologues and 9 paralogues. Biased expression in brain (RPKM 38.1), skin (RPKM 32.4) and 13 other tissues.

Summary

Involved in positive regulation of smooth muscle cell differentiation. Acts upstream of or within protein secretion. Located in cytoplasm; extracellular region; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OLFM2 Products (3)

mRNA Protein Name
NM_001304347.2 NP_001291276.1 noelin-2 isoform 1
NM_001304348.2 NP_001291277.1 noelin-2 isoform 3
NM_058164.4 NP_477512.1 noelin-2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25298399 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
25298399 GOA
acts upstream of or within protein secretion IDA
IDA: Inferred from direct assay
21228389 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25298399 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
21228389 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25298399 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLFM2 Protein Structure

Noelin-1

Noelin-1: Neurogenesis glycoprotein (25 - 121)

OLF

OLF: Olfactomedin-like domain (198 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

noelin-2

  • neuronal olfactomedin related ER localized protein 2

OLFM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OLFM2 O95897 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
OLFM2 O95897 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
OLFM2 O95897 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
Intra
OLFM2 O95897 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
OLFM2 O95897 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Open-Angle Glaucoma

  • Glaucoma Simplex

  • Pigmentary Glaucoma

  • Wide-Angle Glaucoma

  • Glaucoma, Open-Angle

  • Open Angle Glaucoma

  • Glaucoma Open-Angle

  • Chronic Simple Glaucoma

  • Coag - [Chronic Open-Angle Glaucoma]

  • Csg - [Chronic Simple Glaucoma]

  • Poag - [Primary Open-Angle Glaucoma]

  • Oag - [Open-Angle Glaucoma]

  • Chronic Glaucoma

  • Chronic Open Angle Glaucoma

  • Simple Glaucoma

  • Chronic Noncongestive Glaucoma

  • Ltg - [Low Tension Glaucoma]

  • Noncongestive Glaucoma

  • Nonobstructive Glaucoma

  • Normal Pressure Glaucoma

  • Primary Low Tension Glaucoma

  • Low-Tension Glaucoma

  • Residual Stage Low Tension Glaucoma

  • Open Cleft Glaucoma
Arteriosclerosis Obliterans
Glaucoma, Primary Open Angle

  • Glaucoma 1, Open Angle, E

  • Primary Open Angle Glaucoma

  • POAG

  • Adult-Onset Primary Open Angle Glaucoma

  • Chronic Simple Glaucoma

  • GLC1E

  • Primary Open Angle Glaucoma 1e

  • Glaucoma, Open Angle, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09771 OLFM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus OLFM2 RGD RGD:1309741
Bos taurus OLFM2 VGNC VGNC:32418
Macaca mulatta OLFM2 VGNC VGNC:75417
Mus musculus OLFM2 MGD MGI:3045350
Canis familiaris OLFM2 VGNC VGNC:44113
Felis catus OLFM2 VGNC VGNC:63959
Others OLFM2 NCBI