MED26 - mediator complex subunit 26 Gene

Also Known as CRSP7; CRSP70

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9441

About MED26

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,574,919-16,628,204 (from NCBI)

This gene has 7 transcripts (splice variants) and 215 orthologues. Broad expression in testis (RPKM 18.2), bone marrow (RPKM 6.2) and 23 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of Other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

MED26 Products (1)

mRNA	Protein	Name
NM_004831.5	NP_004822.2	mediator of RNA polymerase II transcription subunit 26

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15175163	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	15989967	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15989967	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	15989967	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED26 Protein Structure

Med26

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Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 26	ARC70

MED26 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MED26	O95402	MED4	Homo sapiens	Q9NPJ6	Anti Tag CoIP	15175163
Intra	MED26	O95402	MED4	Homo sapiens	Q9NPJ6	Anti Tag CoIP	21729782
Intra	MED26	O95402	MED4	Homo sapiens	Q9NPJ6	Anti Tag CoIP	24882805
Intra	MED26	O95402	MED7	Homo sapiens	O43513	Anti Tag CoIP	24882805
Intra	MED26	O95402	MED7	Homo sapiens	O43513	Anti Tag CoIP	15175163
Intra	MED26	O95402	MED7	Homo sapiens	O43513	Anti Tag CoIP	21729782
Cross	MED26	O95402	Med19	Mus musculus	Q8C1S0	Anti Tag CoIP	24882805
Intra	MED26	O95402	EAF1	Homo sapiens	Q96JC9	Anti Tag CoIP	21729782

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08297	MED26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MED26	VGNC	VGNC:102636
Mus musculus	MED26	MGD	MGI:1917875
Rattus norvegicus	MED26	RGD	RGD:1309524
Others	MED26	NCBI