2. Gene
  3. MED26 - mediator complex subunit 26 Gene

MED26 - mediator complex subunit 26 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CRSP7; CRSP70

Gene ID: 9441 | Gene type: protein coding

About MED26

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,574,919-16,628,204 (from NCBI)

This gene has 7 transcripts (splice variants) and 215 orthologues. Broad expression in testis (RPKM 18.2), bone marrow (RPKM 6.2) and 23 other tissues.

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

MED26 Products(1)

mRNA Protein Name
NM_004831.5 NP_004822.2 mediator of RNA polymerase II transcription subunit 26

MED26 Protein Structure

Med26

Med26: TFIIS helical bundle-like domain (34 - 84)

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Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 26

ARC70

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08297 MED26 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MED26 VGNC VGNC:102636
Mus musculus MED26 MGD MGI:1917875
Rattus norvegicus MED26 RGD RGD:1309524