2. Gene
  3. SH3BP5 - SH3 domain binding protein 5 Gene

SH3BP5 - SH3 domain binding protein 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SAB; SH3BP-5

Gene ID: 9467 | Gene type: protein coding

About SH3BP5

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:15,254,353-15,341,380 (from NCBI)

This gene has 9 transcripts (splice variants), 276 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 64.1), fat (RPKM 35.1) and 24 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Acts upstream of or within intracellular signal transduction. Located in cytoplasmic vesicle membrane and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

SH3BP5 Products(2)

mRNA Protein Name
NM_001018009.4 NP_001018009.2 SH3 domain-binding protein 5 isoform b
NM_004844.5 NP_004835.2 SH3 domain-binding protein 5 isoform a

SH3BP5 Protein Structure

SH3BP5

SH3BP5: SH3 domain-binding protein 5 (SH3BP5) (37 - 270)

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  • 455 a.a.
Protein Preferred Names Protein Names

SH3 domain-binding protein 5

SH3 domain-binding protein that preferentially associates with BTK

Related Diseases

Diseases Alias
Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia

XLA

Bruton Type Agammaglobulinemia

Bruton'S Agammaglobulinemia

Bruton-Type Agammaglobulinemia

Agmx1

Imd1

Agammaglobulinemia, X-Linked 1

Btk-Deficiency

Agammaglobulinemia

Hypogammaglobulinemia

Agammaglobulinemia, X-Linked, Type 1

Immunodeficiency 1

Bruton Agammaglobulinemia Tyrosine Kinase Deficiency

Bruton Disease

Bruton'S Agammaglobulinaemia

Bruton'S Sex-Linked Agammaglobulinemia

Bruton'S Type Agammaglobulinemia

Btk Deficiency

Agammaglobulinemia, Btk

Agammaglobulinemia, Bruton Tyrosine Kinase

Congenital Agammaglobulinemia

Immunodeficiency Type 1

X-Linked Agammaglobulinemia Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12833 SH3BP5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SH3BP5 MGD MGI:1344391
Felis catus SH3BP5 VGNC VGNC:65103
Rattus norvegicus SH3BP5 RGD RGD:620220
Bos taurus SH3BP5 VGNC VGNC:34568
Canis familiaris SH3BP5 VGNC VGNC:46120
Macaca mulatta SH3BP5 VGNC VGNC:77203