ECE2 - endothelin converting enzyme 2 Gene

Also Known as EEF1AKMT4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9718

About ECE2

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:184,276,022-184,293,031 (from NCBI)

This gene has 9 transcripts (splice variants), 232 orthologues and 6 paralogues. Broad expression in adrenal (RPKM 4.6), brain (RPKM 3.0) and 22 other tissues.

Summary

Enables metalloendopeptidase activity. Involved in peptide hormone processing. Located in cytoplasmic vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]

ECE2 Products (3)

mRNA Protein Name
NM_001037324.3 NP_001032401.1 endothelin-converting enzyme 2 isoform B
NM_001100120.2 NP_001093590.1 endothelin-converting enzyme 2 isoform D
NM_001100121.2 NP_001093591.1 endothelin-converting enzyme 2 isoform E

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
11718899 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in peptide hormone processing IDA
IDA: Inferred from direct assay
11718899 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
11718899 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelin-converting enzyme 2

  • EEF1A lysine methyltransferase 4

Recombinant ECE2 Proteins

Cat. No. Product Name Accession Purity
HY-P75266 ECE-2 Protein, Human (HEK293, His) P0DPD8-1/NP_055508.3 (G120-W883) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75267 ECE-2 Protein, Human (I320, HEK293, hFc) P0DPD8-1 (G200-W883,I320) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Periventricular Nodular Heterotopia

  • Periventricular Heterotopia

  • Pvnh

  • Familial Nodular Heterotopia

  • Heterotopia, Periventricular

  • Periventricular Heterotopia, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04134 ECE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19325 Ece2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25816 Ece2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ECE2 VGNC VGNC:28303
Canis familiaris ECE2 VGNC VGNC:40182
Mus musculus ECE2 MGD MGI:1101356
Others ECE2 NCBI