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SLK - STE20 like kinase Gene

Also Known as LOSK; STK2; se20-9; bA16H23.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9748

About SLK

Cytogenetic location: 10q24.33-q25.1 Genomic coordinates (GRCh38): 10:103,967,140-104,029,233 (from NCBI)

This gene has 4 transcripts (splice variants), 273 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 35.4), lung (RPKM 15.9) and 25 other tissues.

Summary

Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic microtubule organization; protein autophosphorylation; and regulation of focal adhesion assembly. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SLK Products (2)

mRNA	Protein	Name
NM_001304743.2	NP_001291672.1	STE20-like serine/threonine-protein kinase isoform 2
NM_014720.4	NP_055535.2	STE20-like serine/threonine-protein kinase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	18239682	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25882817	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18239682	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18239682	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	18287541	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18239682	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	22203681	GOA
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	26818812	GOA
involved in regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	23128389	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18287541	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	26094769	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLK Protein Structure

Pkinase

PKK

0
200
400
600
800
1000
1235 a.a.

Protein Preferred Names	Protein Names
STE20-like serine/threonine-protein kinase	CTCL tumor antigen se20-9

SLK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLK	Q9H2G2	HSPA9	Homo sapiens	P38646	Crosslink	30021884
Intra	SLK	Q9H2G2	SLK	Homo sapiens	Q9H2G2	Crosslink	18239682
Intra	SLK	Q9H2G2	SLK	Homo sapiens	Q9H2G2	X-Ray Diffraction	18239682
Intra	SLK	Q9H2G2	a0a380pi90_yerpe	Yersinia pestis	A0A380PI90	Y2H Pooling	20711500
Intra	SLK	Q9H2G2	SLK	Homo sapiens	Q9H2G2	Solution Sedimentation	18239682
Intra	SLK	Q9H2G2	AIFM1	Homo sapiens	O95831	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Advanced Sleep Phase Syndrome, Familial, 1	Advanced Sleep Phase Syndrome 1 FASPS1 Familial Advanced Sleep Phase Syndrome 1 Sleep Phase Syndrome, Advanced, Familial, Type 1
Advanced Sleep Phase Syndrome, Familial, 3	Advanced Sleep Phase Syndrome 3 FASPS3 Familial Advanced Sleep Phase Syndrome 3 Sleep Phase Syndrome, Advanced, Familial, Type 3
Acute Kidney Failure	Acute Renal Failure Acute Kidney Injury Renal Failure Acute Kidney Failure, Acute Pre-Renal Acute Kidney Injury Nontraumatic Acute Kidney Injury Aki - [Acute Kidney Injury] Arf - [Acute Kidney Failure] Acute Kidney Disease Acute Kidney Impairment Acute Ischaemic Renal Failure Acute Hypoxic Kidney Failure Acute Kidney Shutdown Acute Renal Oedema Acute Renal Impairment Acute Kidney Collapse Acute Necrotising Kidney Acute Renal Suppression
Inflammatory Bowel Disease 7	IBD7
Autoimmune Glomerulonephritis
Alzheimer Disease 3	AD3 Alzheimer Disease, Type 3 Alzheimer Disease, Type 3, With Spastic Paraparesis And Apraxia Alzheimer Disease, Type 3, With Spastic Paraparesis And Unusual Plaques Alzheimer'S Disease 3 Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Apraxia Alzheimer Disease 3, Early-Onset Alzheimer Disease, Familial, 3 Alzheimer Disease, Protection Against, Due To Apoe3-Christchurch Alzheimer Disease 3, Early Onset Alzheimer Disease Familial 3 Early-Onset Familial Alzheimer Disease 3 Familial Alzheimer Disease 3 Familial Alzheimer Disease 3 With Spastic Paraparesis And Apraxia Familial Alzheimer Disease 3 With Spastic Paraparesis And Unusual Plaques Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Unusual Plaques Alzheimer Disease, Familial, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117393	Bisindolylmaleimide III	Inhibitor	98.95%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLK	RGD	RGD:3780
Mus musculus	SLK	MGD	MGI:103241
Felis catus	SLK	VGNC	VGNC:97634
Macaca mulatta	SLK	VGNC	VGNC:81575
Bos taurus	SLK	VGNC	VGNC:34968
Canis familiaris	SLK	VGNC	VGNC:46512
Others	SLK	NCBI