SPOCK2 - SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 Gene

Also Known as testican-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9806

About SPOCK2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,059,034-72,089,032 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 3 paralogues. Biased expression in lung (RPKM 58.9), brain (RPKM 55.4) and 13 other tissues.

Summary

This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

SPOCK2 Products (3)

mRNA Protein Name
NM_001134434.1 NP_001127906.1 testican-2 isoform 1 precursor
NM_001244950.2 NP_001231879.1 testican-2 isoform 2 precursor
NM_014767.2 NP_055582.1 testican-2 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
10386950 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPOCK2 Protein Structure

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (139 - 180)

SPARC_Ca_bdg

SPARC_Ca_bdg: Secreted protein acidic and rich in cysteine Ca binding region (197 - 305)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (313 - 376)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
Protein Preferred Names Protein Names

testican-2

  • SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2

SPOCK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPOCK2 Q92563 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13696 SPOCK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SPOCK2 VGNC VGNC:46751
Macaca mulatta SPOCK2 VGNC VGNC:106105
Rattus norvegicus SPOCK2 RGD RGD:1308568
Mus musculus SPOCK2 MGD MGI:1891351
Bos taurus SPOCK2 VGNC VGNC:35226
Others SPOCK2 NCBI