PSMD6 - proteasome 26S subunit, non-ATPase 6 Gene

Also Known as S10; Rpn7; p42A; p44S10; SGA-113M

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9861

About PSMD6

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:64,010,551-64,024,007 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 47.2), bone marrow (RPKM 29.6) and 25 other tissues.

Summary

This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S Proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

PSMD6 Products (4)

mRNA Protein Name
NM_001271779.2 NP_001258708.1 26S proteasome non-ATPase regulatory subunit 6 isoform 1
NM_001271780.2 NP_001258709.1 26S proteasome non-ATPase regulatory subunit 6 isoform 3
NM_001271781.2 NP_001258710.1 26S proteasome non-ATPase regulatory subunit 6 isoform 4
NM_014814.3 NP_055629.1 26S proteasome non-ATPase regulatory subunit 6 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16990800 GOA
Cellular Component GO Annotation Evidence References Source
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD6 Protein Structure

RPN7

RPN7: 26S proteasome subunit RPN7 (66 - 239)

PCI

PCI: PCI domain (254 - 357)

  • 0
  • 100
  • 200
  • 300
  • 389 a.a.
Protein Preferred Names Protein Names

26S proteasome non-ATPase regulatory subunit 6

  • breast cancer-associated protein SGA-113M

PSMD6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSMD6 Q15008 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
PSMD6 Q15008 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
PSMD6 Q15008 CMTM7 Homo sapiens Q96FZ5
Y2H Prey Pooling
32296183
Intra
PSMD6 Q15008 CMTM7 Homo sapiens Q96FZ5
Y2H Array
32296183
Intra
PSMD6 Q15008 CMTM7 Homo sapiens Q96FZ5
Validated Y2H
32296183
Intra
PSMD6 Q15008 PSMD4 Homo sapiens P55036
Anti Bait CoIP
17353931
Intra
PSMD6 Q15008 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
PSMD6 Q15008 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
PSMD6 Q15008 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11327 PSMD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PSMD6 VGNC VGNC:69126
Rattus norvegicus PSMD6 RGD RGD:735127
Mus musculus PSMD6 MGD MGI:1913663
Canis familiaris PSMD6 VGNC VGNC:54345
Bos taurus PSMD6 VGNC VGNC:33470
Macaca mulatta PSMD6 VGNC VGNC:76454