Cul4a - cullin 4A Gene

Also Known as 2810470J21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 99375

Summary

Predicted to enable ubiquitin protein Ligase binding activity and ubiquitin-protein transferase activity. Involved in in utero embryonic development and ribosome biogenesis. Acts upstream of or within several processes, including negative regulation of granulocyte differentiation; positive regulation of G1/S transition of mitotic cell cycle; and regulation of response to DNA damage stimulus. Predicted to be part of Cul4A-RING E3 ubiquitin Ligase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and musculoskeletal system. Orthologous to human CUL4A (cullin 4A). [provided by Alliance of Genome Resources, Apr 2022]

Cul4a Products (3)

mRNA Protein Name
NM_001363448.1 NP_001350377.1 cullin-4A isoform 2
NM_001363450.1 NP_001350379.1 cullin-4A isoform 3
NM_146207.3 NP_666319.2 cullin-4A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16467204 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA damage response EXP
EXP: Inferred from Experiment
22118460 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
16467204 MGI
involved in cellular response to UV EXP
EXP: Inferred from Experiment
22118460 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
18339895 MGI
involved in in utero embryonic development IMP
IMP: Inferred from mutant phenotype
12077329 MGI
acts upstream of or within negative regulation of granulocyte differentiation IDA
IDA: Inferred from direct assay
12393421 MGI
acts upstream of or within positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19056892 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16467204 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16467204 MGI
acts upstream of or within regulation of DNA damage checkpoint IMP
IMP: Inferred from mutant phenotype
19481525 MGI
acts upstream of or within regulation of nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
19481525 MGI
acts upstream of or within regulation of protein metabolic process IMP
IMP: Inferred from mutant phenotype
19056892 MGI
involved in ribosome biogenesis IMP
IMP: Inferred from mutant phenotype
26711351 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
17616641 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19481525 MGI
Cellular Component GO Annotation Evidence References Source
part of Cul4A-RING E3 ubiquitin ligase complex EXP
EXP: Inferred from Experiment
22118460 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cullin-4A

  • CUL-4A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148602 KH-4-43 Inhibitor 99.72% Unkown
HY-161166 MM-02-57 / Unkown
HY-181164 PROTAC BRD4 Degrader-43 / Unkown
HY-P11640 Vpr (1-14) Inhibitor / Unkown
HY-RS03362 CUL4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22460 Cul4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28983 Cul4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cul4a NCBI NCBI:8451