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Cat. No.: HY-404047

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GS-1427 intermediate-2

GS-1427 intermediate-2 is a key intermediate in the synthesis of GS-1427 (HY-175745).

For research use only. We do not sell to patients.

CAS No.: 2417310-64-4
Formula: C₄₀H₃₃N₅O₄
Molecular Weight:647.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

GS-1427 intermediate-2 Chemical Structure

CAS No.: 2417310-64-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

GS-1427 intermediate-2 is a key intermediate in the synthesis of GS-1427 (HY-175745)^[1].

Chemical Information

CAS No. 2417310-64-4
Molecular Weight 647.72
Formula C₄₀H₃₃N₅O₄
SMILES

O=C(C1=CC=NC=C1N(C2=O)C)N2C3=CC=C(C4=C3N=CC=C4)C[C@@H](C(OC)=O)NC(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Leena Patel, et al. Discovery of GS-1427: A potent and selective, oral α4β7 inhibitor for the treatment of inflammatory bowel disease. ACS. 2025 Aug 20.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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