2. Cell Cycle/DNA Damage Anti-infection Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis SARS-CoV RSV HCV Drug Metabolite
  4. GS-443902 trisodium

GS-443902 trisodium  (Synonyms: GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium)

製品番号: HY-126303C 純度: 99.94%
COA 取扱説明書 Technical Support

GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734).

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GS-443902 trisodium

GS-443902 trisodium 構造式

CAS 番号 : 1355050-21-3

容量 価格（税別） 在庫状況 数量
1 mg $450 在庫あり
5 mg $1120 在庫あり
10 mg $1680 在庫あり
25 mg $3100 在庫あり
50 mg $4650 在庫あり
100 mg $7000 在庫あり
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Based on 13 publication(s) in Google Scholar

Other Forms of GS-443902 trisodium:

GS-443902 trisodium 関連抗体

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製品説明

GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2].

IC50 & Target

IC50: 1.1 μM (RSV RdRp) and 5 μM (HCV RdRp)[1][2]
体外実験

In a continuous 72 h incubation of 1 μM Remdesivir (GS-5734), the GS-443902 trisodium (GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium) level is measured at 2, 24, 48 and 72 h, and reaches a Cmax of 300, 110, and 90 pmol/million cells in macrophages, HMVEC, and HeLa cells lines respectively[1].
GS-443902 trisodium (compound 8a) is a triphosphates (TP) derivative[2].
GS-443902 trisodium (NTP; 0.01, 0.1, 1, 10, 100 μM) inhibits RSV RdRp-catalysed RNA synthesis by incorporating into the nascent viral RNA transcript and causing its premature termination. GS-5734 selectively inhibits EBOV replication by targeting its RdRp and inhibiting viral RNA synthesis following efficient intracellular conversion to GS-443902 sodium[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GS-443902 trisodium 関連抗体
体内実験

Remdesivir (GS-5734; 10 mg kg; i.v.) rapidly distributes into peripheral blood mononuclear cells (PBMCs), and efficient conversion to GS-443902 trisodium (Remdesivir metabolite trisodium; NTP) is apparent within 2 h of dose administration in rhesus monkeys. In PBMCs, GS-443902 trisodium represents the predominant metabolite and is persistent with a t1/2 of 14 h and levels required for >50% virus inhibition for 24 hours[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

597.15

分子式

C12H13N5Na3O13P3
CAS 番号
Appearance

Solid

Color

White to light yellow

SMILES

O=P(OP(O)(O[Na])=O)(O[Na])OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O[Na])=O
輸送条件

Shipping with dry ice.
保管条件

-80°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.
溶剤 & 溶解度
体外: 

H2O : 33.33 mg/mL (55.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6746 mL 8.3731 mL 16.7462 mL
5 mM 0.3349 mL 1.6746 mL 3.3492 mL
10 mM 0.1675 mL 0.8373 mL 1.6746 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (83.73 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.94%

COA (253 KB) HNMR (379 KB) RP-HPLC (204 KB) LCMS (98 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6746 mL 8.3731 mL 16.7462 mL 41.8655 mL
5 mM 0.3349 mL 1.6746 mL 3.3492 mL 8.3731 mL
10 mM 0.1675 mL 0.8373 mL 1.6746 mL 4.1866 mL
15 mM 0.1116 mL 0.5582 mL 1.1164 mL 2.7910 mL
20 mM 0.0837 mL 0.4187 mL 0.8373 mL 2.0933 mL
25 mM 0.0670 mL 0.3349 mL 0.6698 mL 1.6746 mL
30 mM 0.0558 mL 0.2791 mL 0.5582 mL 1.3955 mL
40 mM 0.0419 mL 0.2093 mL 0.4187 mL 1.0466 mL
50 mM 0.0335 mL 0.1675 mL 0.3349 mL 0.8373 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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GS-443902 trisodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-443902 trisodium1355050-21-3GS-441524 triphosphate trisodium Remdesivir metabolite trisodiumDNA/RNA SynthesisSARS-CoVRSVHCVDrug MetaboliteSARS coronavirusRespiratory syncytial virusHepatitis C virustriphosphatemetaboliteRemdesivirGS-5734RNA-dependentRNA-polymerasesRdRpTPGS-441524Inhibitorinhibitorinhibit

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