2. PI3K/Akt/mTOR Stem Cell/Wnt Autophagy
  3. GSK-3 Mitophagy
  4. GSK3-IN-3

GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA.

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GSK3-IN-3

GSK3-IN-3 Estructura química

No. CAS : 331963-27-0

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Based on 4 publication(s) in Google Scholar

GSK3-IN-3 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Descripciòn

GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA[1][2][3].

IC50 & Target

IC50: 3.01 μM (GSK-3)[3]
In Vitro

GSK3-IN-3 (VP07) (25 μM; 24 h) induces mitophagy in Parkin-expressing U2OS-iMLS cells with restricted potency[1].
GSK3-IN-3 (1.56-25 μM; 24 h) results in mitochondria fission with mitochondrial morphology change in U2OS-iMLS-Parkin cells[1].
GSK3-IN-3 (VP0.7) (5 μM, 10 μM; ) shows neuroprotection against 6-OHDA albeit in a Parkinson's disease in vitro cellular model in SH-SY5Y cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK3-IN-3 Related Antibodies

Immunofluorescence[1]

Cell Line: Parkin-expressing U2OS-iMLS cells
Concentration: 1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM, and 25 μM;
Incubation Time: 24 hours
Result: Induced a mitochondrial morphology change from a filament-shaped network to a more round-shaped network.

Cell Viability Assay[2]

Cell Line: SH-SY5Y cells
Concentration: 0.5 μM, 1 μM, 3 μM, 5 μM, and 10 μM
Incubation Time: 16 hours; with 35 μM 6-OHDA
Result: Inhibited cell growth with an IC50 value of 2.57 μM.
Peso molecular

429.55

Fòrmula

C24H35N3O4
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C(N(CC)C2=C(C1=O)C=CC=C2)O)NNC(CCCCCCCCCCC)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 4.17 mg/mL (9.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3280 mL 11.6401 mL 23.2802 mL
5 mM 0.4656 mL 2.3280 mL 4.6560 mL
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* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3280 mL 11.6401 mL 23.2802 mL 58.2004 mL
5 mM 0.4656 mL 2.3280 mL 4.6560 mL 11.6401 mL
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GSK3-IN-3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK3-IN-3331963-27-0GSK-3MitophagyGlycogen synthase kinase-3Glycogen synthase kinase 3Mitochondrial AutophagyInhibitorinhibitorinhibit

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Nombre del producto:
GSK3-IN-3
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HY-153089
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