331963-27-0
331963-27-0
Chemical Structure
GSK3-IN-3
- CAS No.: 331963-27-0
- Formula:C24H35N3O4
- Molecular Weight:429.55
IUPAC Name: N'-dodecanoyl-1-ethyl-2-hydroxy-4-oxo-1,4-dihydroquinoline-3-carbohydrazide
InChIKey: QNULHCXPEZSPNO-UHFFFAOYSA-N
SMILES: O=C(C1=C(N(CC)C2=C(C1=O)C=CC=C2)O)NNC(CCCCCCCCCCC)=O
Biological Activity: GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK3-IN-3 | 99.22% | GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.77
HY-76293I2906 -
Similarity Score 0.54
HY-N16381-Methyl-2-undecyl-4(1H)-quinolone -
Similarity Score 0.53
HY-N2517Dihydroevocarpine -
Similarity Score 0.51
HY-145080Dynole 2−24 -
Similarity Score 0.50
HY-12317GSA-10 -
Similarity Score 0.50
HY-N16361-Methyl-2-nonyl-4(1H)-quinolone -
Similarity Score 0.49
HY-131678Palmitoyl serotonin -
Similarity Score 0.49
HY-105518Terbequinil -
Similarity Score 0.48
HY-121465Stearoyl Serotonin -
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References
- [1]. Maestro I, et al. Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease. ACS Chem Neurosci. 2021 Dec 15;12(24):4512-4523. [Content Brief]
- [2]. Morales-García JA, et al. Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease. ACS Chem Neurosci. 2013 Feb 20;4(2):350-60. [Content Brief]
- [3]. Palomo V, et al. Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities. J Med Chem. 2011 Dec 22;54(24):8461-70. [Content Brief]
